Evidence map›Paper›PMID 34491806›Full record

ArticleAntimicrobial agents and chemotherapy2021

Antibiotic Use and Bacterial Infection among Inpatients in the First Wave of COVID-19: a Retrospective Cohort Study of 64,691 Patients.

Jonathan D Baghdadi, K C Coffey, Timileyin Adediran, Katherine E Goodman, Lisa Pineles, Larry S Magder, Lyndsay M O'Hara, Beth L Pineles, Gita Nadimpalli, Daniel J Morgan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
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  13. Early empiric antibiotic use in COVID-19 patients: results from the international VIRUS registry.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
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  14. Article
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  16. Antimicrobial use before and during COVID-19: data from 108 Veterans Affairs medical centers.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024
    Article
  17. [Bacterial coinfection in the critically-ill COVID-19 patient: incidence, impact and need for antimicrobial therapy].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jonathan D BaghdadiDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2442-0654
K C CoffeyDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Timileyin AdediranUniversity of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Katherine E GoodmanDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Lisa PinelesDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Larry S MagderDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Lyndsay M O'HaraDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Beth L PinelesDepartment of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Gita NadimpalliDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Daniel J MorganDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Anthony D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
University of Maryland, Baltimore · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
NCATS NIH HHS KL2 TR003099NCATS NIH HHS UL1 TR003098
6 · The paper itself

Abstract

Hospitalized patients with SARS-CoV-2 infection (COVID-19) often receive antibiotics for suspected bacterial coinfection. We estimated the incidence of bacterial coinfection and secondary infection in COVID-19 using clinical diagnoses to determine how frequently antibiotics are administered when bacterial infection is absent. We performed a retrospective cohort study of inpatients with COVID-19 present on admission to hospitals in the Premier Healthcare Database between April and June 2020. Bacterial infections were defined using ICD-10-CM diagnosis codes and associated "present on admission" coding. Coinfections were defined by bacterial infection present on admission, while secondary infections were defined by bacterial infection that developed after admission. Coinfection and secondary infection were not mutually exclusive. A total of 18.5% of 64,961 COVID-19 patients (

Indexed as

Bacterial InfectionsCoinfectionCOVID-19Anti-Bacterial AgentsHospitalizationHumansInpatientsRetrospective StudiesSARS-CoV-2Anti-Bacterial Agentsantibioticsbacterial coinfectionCOVID-19secondary infection

Identifiers

PMID34491806
PMCPMC8522758
OpenAlexW3198525884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.