Evidence map›Paper›PMID 34491804›Full record

ArticleAntimicrobial agents and chemotherapy2021

Echinocandins Accelerate Particle Transport Velocity in the Murine Tracheal Epithelium: Dependency on Intracellular Ca

Sabrina Müller, Maximilian Carl Droll, Christian Koch, Sebastian Weiterer, Markus A Weigand, Michael Sander, Michael Henrich

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sabrina Müller *Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Maximilian Carl Droll *Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Christian KochDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Sebastian WeitererDepartment of Anaesthesiology and Intensive Care Medicine, Lukas Hospital Rheinland Clinic Neuss GmbH, Neuss, Germany.
Markus A WeigandDepartment of Anaesthesiology and Intensive Care Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Michael SanderDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Michael HenrichDepartment of Anaesthesiology, Intensive Care Medicine, Emergency Medicine, Vidia St. Vincentius-Clinic Karlsruhe gAG, Karlsruhe, Germany.ORCID 0000-0002-2541-546X
Universitätsklinikum Gießen und Marburg · DEHeidelberg University · DELukaskrankenhaus · DESt. Vincentius-Kliniken · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mucociliary clearance of lower airways is modulated by different physiologic stimuli and also by pathophysiologic agents like polluting substances or pharmaceutical molecules. In the present investigation, we measured the particle transport velocity (PTV) of mouse tracheae as a surrogate for mucociliary clearance. In mouse tracheal preparations, we detected a sustained increase in the PTV under the application of the echinocandins caspofungin, anidulafungin, and micafungin. In further experiments, we observed the effects of echinocandins on the PTV were dependent on intracellular Ca

Indexed as

Antifungal AgentsEchinocandinsAnidulafunginAnimalsCaspofunginEpitheliumMiceAnidulafunginAntifungal AgentsCaspofunginEchinocandinsantifungal agentsechinocandinsintracellular calciummucociliary clearanceparticle transport velocity

Identifiers

PMID34491804
PMCPMC8522769
OpenAlexW3197256641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.