Evidence map›Paper›PMID 34491789›Full record

ArticleInfection and immunity2021

Nitric Oxide Inhibition of Rickettsia rickettsii.

Liam F Fitzsimmons, Tina R Clark, Ted Hackstadt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. mBio · 2024
    Article
  4. Infection and immunity · 2022
    Review
  5. Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Liam F FitzsimmonsHost-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Tina R ClarkHost-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Ted HackstadtHost-Parasite Interactions Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0003-1367-5528
National Institutes of Health · US

Funding

Biology of RickettsiaZ01AI000977 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HACKSTADT, DAVID (TED) · 2006 to 2008
$1.7M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID) Z01-AI000977Intramural NIH HHS Z01 AI000977
6 · The paper itself

Abstract

Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, is an enzootic, obligate, intracellular bacterial pathogen. Nitric oxide (NO) synthesized by the inducible NO synthase (iNOS) is a potent antimicrobial component of innate immunity and has been implicated in the control of virulent

Indexed as

Host-Pathogen InteractionsEnergy MetabolismImmunity, InnateMacrophagesNitric OxideNitric Oxide Synthase Type IIRickettsia rickettsiiRocky Mountain Spotted FeverNitric OxideNitric Oxide Synthase Type IIhost defenseinnate immunitynitric oxideRickettsia

Identifiers

PMID34491789
PMCPMC8594597
OpenAlexW3198763644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.