ReviewInorganic chemistry2021
C-H Bond Cleavage by Bioinspired Nonheme Metal Complexes.
Review in Inorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Beyond the Oxo-Wall: Synthesis and Reactivity of a Six-Coordinate Formally CoAngewandte Chemie (International ed. in English) · 2026Article
- Bimetallic Chemistry by Design: Approaches to the Development of Multifunctional Ligands.Coordination chemistry reviews · 2026Article
- Asymmetric Hydrogen Atom Transfer.ACS catalysis · 2026Review
- Million-Fold Activation of C-H Bonds by Fluorinated Nonheme FeACS catalysis · 2025Article
- Basicity-Controlled C-H Bond Activation by a Structurally Characterized Ni(III)-Hydroxo Complex.Journal of the American Chemical Society · 2025Article
- Intramolecular Oxo Atom Migration to theJournal of the American Chemical Society · 2025Article
- Generation of [(N4Py)Fe(IV)═O]Inorganic chemistry · 2025Article
- Impact of Secondary Sphere Hydrogen Bonds on OJournal of the American Chemical Society · 2025Article
- Flash Communication: Flexibility of a Biologically Inspired Ligand Framework for Intramolecular C-H Activation.Organometallics · 2025Article
- Proton-Induced Switching of Paramagnetism: Reversible Conversion between a Low and High Spin CoJournal of the American Chemical Society · 2025Article
- An Open-Shell FeJournal of the American Chemical Society · 2025Article
- Chemical methods to stabilize segments of metalloproteins in the form of peptides.Methods in enzymology · 2025Article
- Electron transfer in biological systems.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024Review
- Effect of Substituted Pyridine Co-Ligands and (Diacetoxyiodo)benzene Oxidants on the Fe(III)-OIPh-Mediated Triphenylmethane Hydroxylation Reaction.Molecules (Basel, Switzerland) · 2024Article
- Iron-Catalyzed C-H Oxygenation Using Perchlorate Enabled by Secondary Sphere Hydrogen Bonds.Journal of the American Chemical Society · 2024Article
- Catalyst and Medium Control over Rebound Pathways in Manganese-Catalyzed Methylenic C-H Bond Oxidation.Journal of the American Chemical Society · 2024Article
- Iron(iv) alkyl complexes: electronic structure contributions to Fe-C bond homolysis and migration reactions that form N-C bonds from NChemical science · 2024Article
- Modulation of the Bonding between Copper and a Redox-Active Ligand by Hydrogen Bonds and Its Effect on Electronic Coupling and Spin States.Journal of the American Chemical Society · 2024Article
- Influence of Equatorial Co-Ligands on the Reactivity of LFeMolecules (Basel, Switzerland) · 2023Article
- Generation, Spectroscopic Characterization, and Computational Analysis of a Six-Coordinate Cobalt(III)-Imidyl Complex with an UnusualJournal of the American Chemical Society · 2023Article
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5 authors.
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Abstract
The functionalization of C-H bonds is one of the most challenging transformations in synthetic chemistry. In biology, these processes are well-known and are achieved with a variety of metalloenzymes, many of which contain a single metal center within their active sites. The most well studied are those with Fe centers, and the emerging experimental data show that high-valent iron oxido species are the intermediates responsible for cleaving the C-H bond. This Forum Article describes the state of this field with an emphasis on nonheme Fe enzymes and current experimental results that provide insights into the properties that make these species capable of C-H bond cleavage. These parameters are also briefly considered in regard to manganese oxido complexes and Cu-containing metalloenzymes. Synthetic iron oxido complexes are discussed to highlight their utility as spectroscopic and mechanistic probes and reagents for C-H bond functionalization. Avenues for future research are also examined.
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