ArticleJournal of endocrinological investigation2022
Development and validation of an individualized nomogram for predicting the high-volume (> 5) central lymph node metastasis in papillary thyroid microcarcinoma.
Article in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- A nomogram for predicting high-volume central lymph node metastasis in unilateral clinically node-negative papillary thyroid microcarcinoma.Gland surgery · 2026Article
- Surgical Optimization in Preoperatively Low-risk cN1a PTC: A Predictive Model for High-Volume Central Lymph Node Metastasis.Annals of surgical oncology · 2026Article
- Article
- Preoperative prediction of central lymph node metastasis in clinically lymph node negative papillary thyroid microcarcinoma: a nomogram based on clinical and ultrasound features.BMC medical imaging · 2025Article
- Evaluation of predictive factors for lymph node metastasis in thyroid microcarcinoma: a two-year experience from two high-volume centers.Updates in surgery · 2025Article
- Nomograms for predicting cervical central lymph node metastases and high-volume cervical central lymph node metastases in papillary thyroid carcinoma.Gland surgery · 2025Article
- Rapid progression and extensive lymph node metastases of papillary thyroid carcinoma in an HIV-positive patient: a Case Report.Frontiers in medicine · 2025Article
- Construction of a predictive model for cervical lymph node metastasis in papillary thyroid carcinoma.Frontiers in oncology · 2025Article
- Is conservative treatment always safe in unifocal clinically T1a/node-negative papillary thyroid carcinoma?World journal of surgery · 2025Article
- Central Neck Dissection in Papillary Thyroid Carcinoma: Benefits and Doubts in the Era of Thyroid Lobectomy.Biomedicines · 2024Article
- Development and validation of a clinical predictive model for high-volume lymph node metastasis of papillary thyroid carcinoma.Scientific reports · 2024Article
- Papillary thyroid carcinoma: ≤ 10 mm does not always mean pN0. A multicentric real-world study.Updates in surgery · 2024Article
- A multivariable model of ultrasound and biochemical parameters for predicting high-volume lymph node metastases of papillary thyroid carcinoma with Hashimoto's thyroiditis.Frontiers in endocrinology · 2024Article
- Cervical lymph node metastasis prediction of postoperative papillary thyroid carcinoma beforeFrontiers in endocrinology · 2023Article
- A practical dynamic nomogram model for predicting bone metastasis in patients with thyroid cancer.Frontiers in endocrinology · 2023Article
- A novel nomogram for identifying high-risk patients among active surveillance candidates with papillary thyroid microcarcinoma.Frontiers in endocrinology · 2023Article
- Nomogram for preoperative prediction of high-volume lymph node metastasis in the classical variant of papillary thyroid carcinoma.Frontiers in surgery · 2023Article
- Nomogram for predicting central lymph node metastasis in T1-T2 papillary thyroid cancer with no lateral lymph node metastasis.Frontiers in endocrinology · 2023Article
- Cervical Lymph Node Metastasis Differences in Patients with Unilateral or Bilateral Papillary Thyroid Microcarcinoma: A Multi-Center Analysis.Journal of clinical medicine · 2022Article
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13 authors.
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Abstract
purposePapillary thyroid microcarcinoma (PTMC) frequently presents a favorable clinical outcome, while aggressive invasiveness can also be found in some of this population. Identifying the risk clinical factors of high-volume (> 5) central lymph node metastasis (CLNM) in PTMC patients could help oncologists make a better-individualized clinical decision.
methodsWe retrospectively reviewed the clinical characteristics of adult patients with PTC in the Surveillance, Epidemiology, and End Results (SEER) database between Jan 2010 and Dec 2015 and in one medical center affiliated to Chongqing Medical University between Jan 2018 and Oct 2020. Univariate and multivariate logistic regression analyses were used to determine the risk factors for high volume of CLNM in PTMC patients.
resultsThe male gender (OR = 2.02, 95% CI 1.46-2.81), larger tumor size (> 5 mm, OR = 1.64, 95% CI 1.13-2.38), multifocality (OR = 1.87, 95% CI 1.40-2.51), and extrathyroidal invasion (OR = 3.67; 95% CI 2.64-5.10) were independent risk factors in promoting high-volume of CLNM in PTMC patients. By contrast, elderly age (≥ 55 years) at diagnosis (OR = 0.57, 95% CI 0.40-0.81) and PTMC-follicular variate (OR = 0.60, 95% CI 0.42-0.87) were determined as the protective factors. Based on these indicators, a nomogram was further constructed with a good concordance index (C-index) of 0.702, supported by an external validating cohort with a promising C-index of 0.811.
conclusionA nomogram was successfully established and validated with six clinical indicators. This model could help surgeons to make a better-individualized clinical decision on the management of PTMC patients, especially in terms of whether prophylactic central lymph node dissection and postoperative radiotherapy should be warranted.
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