Evidence map›Paper›PMID 34491483›Full record

ArticleMolecular biology reports2021

Phenotype and pathological significance of MCAM

Smriti K Raychaudhuri, Christine Abria, Siba P Raychaudhuri

Open access · hybridAbstract read
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. From PsO to PsA: the role of TFrontiers in medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Smriti K RaychaudhuriUniversity of California Davis School of Medicine, Sacramento, USA.
Christine AbriaSacramento VA Medical Center, 10535 Hospital Way, Mather, CA, 95655, USA.
Siba P RaychaudhuriUniversity of California Davis School of Medicine, Sacramento, USA. sraychaudhuri@ucdavis.edu.ORCID http://orcid.org/0000-0001-7594-6528
University of California System · USSacramento VA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146

methodsHi-D FACS studies were done to identify IL-17 in CD4

resultsWe observed that effector CD146

conclusionAs CD146

Indexed as

Arthritis, PsoriaticArthritis, RheumatoidCD146 AntigenFemaleHumansImmunologic MemoryInflammationInterleukin-17Lymphocyte SubsetsMaleMiddle AgedPhenotypeSynovial MembraneT-LymphocytesCD146 AntigenInterleukin-17MCAM protein, humanCD146CytokinesMCAMPsoriatic arthritisT-cells

Identifiers

PMID34491483
PMCPMC8481216
OpenAlexW3198042657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.