ArticleOdontology2022
An in-vivo study of photobiomodulation using 403 nm and 649 nm diode lasers for molar tooth extraction wound healing in wistar rats.
Article in Odontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of photobiomodulation therapy on wound healing and post-extraction pain management of primary molars: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Extraoral low-level laser therapy can decrease pain but not edema and trismus after surgical extraction of impacted mandibular third molars: a randomized, placebo-controlled clinical trial.BMC oral health · 2022Trial
- From light to healing: photobiomodulation therapy in medical disciplines.Journal of translational medicine · 2025Review
- Low-power red laser and ultraviolet A LED irradiation reduces mRNA levels from telomere maintenance genes in Saccharomyces cerevisiae.Lasers in medical science · 2025Article
- Green synthesis of silver nanoparticles with grape seed extract and blue laser activation forVeterinary world · 2025Article
- Green synthesis of silver nanoparticles from shallot extract for potent antifungal activity enhanced by blue diode laser irradiation against candida albicans.Lasers in medical science · 2025Article
- Effectiveness of 808 nm Near Infrared (NIR) Laser Photobiomodulation for Accelerating Postoperative Wound Healing.Journal of lasers in medical sciences · 2025Article
- Photobiomodulation effect of infra-red laser on the level of gonad maturity in the Simese Catfish (Heliyon · 2023Article
- Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing.Journal of biomedical science · 2023Review
- Photobiomodulation at molecular, cellular, and systemic levels.Lasers in medical science · 2023Review
- Effectiveness of ozone-laser photodynamic combination therapy for healing wounds infected with methicillin-resistantVeterinary world · 2023Article
- Article
- Comparison of the antimicrobial reduction effect of photodynamic inactivation with the addition of chlorophyll and curcumin photosensitizer inF1000Research · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThis study aims to examine the effects of red 649 nm 4 J/cm
methodsSamples of 54 Wistar rats were divided into six groups: C- control group without treatment; C + wounded group without treatment; TB wound group with Povidone-iodine treatment; TD wounded group with doxycycline treatment; TLB wounded group with 403 nm diode laser treatment; and TLR wounded group with 649 nm diode laser treatment. Mandibular samples were observed for the number of lymphocytes and fibroblasts cells, new blood vessels formation, Interleukin 1β, and Collagen 1α expression level.
resultsBased on the histopathological test results, red laser diode treatment significantly increased the number of lymphocyte, fibroblast cells and the formation of new blood vessels. Meanwhile, immunohistochemical tests showed an increase in the expression of the Colagen-1α protein which plays a role in the formation of collagen for new tissues formation after damage, as well as a decrease in Interleukin-1β expression level. Blue laser is also able to show a positive effect on wound healing even though its penetration level into the tissue is lower compared to red laser.
conclusionThe red diode laser 649 nm has been shown to accelerate the process of proliferation in wound healing post molar extraction based on histopathological and immunohistochemical test results.
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Registered trials
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