ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2022
Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment-seeking individuals with alcohol use disorder.Alcohol, clinical & experimental research · 2025Trial
- Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Assessing Autonomic Regulation Under Stress with the Yale Pain Stress Test in Social Drinking and Alcohol Use Disorder.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder.Addiction biology · 2024Article
- Heart rate variability: A primer for alcohol researchers.Alcohol (Fayetteville, N.Y.) · 2024Article
- Altered brain and physiological stress responses in early psychosis.Schizophrenia research · 2024Article
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation.Neurobiology of stress · 2024Article
- Vagus nerve damage increases alcohol intake and preference in a nonpreferring rat line: Relationship to vagal regulation of the hypothalamic-pituitary-adrenal axis.Alcohol, clinical & experimental research · 2024Article
- Sex differences in heart rate variability measures that predict alcohol drinking in rats.Addiction biology · 2024Article
- Heart Rate Variability during Online Video Game Playing in Habitual Gamers: Effects of Internet Addiction Scale, Ranking Score and Gaming Performance.Brain sciences · 2023Article
- Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Observational
- Heart rate variability measures indicating sex differences in autonomic regulation during anxiety-like behavior in rats.Frontiers in psychiatry · 2023Article
- Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors.Frontiers in behavioral neuroscience · 2022Review
- The altered functional connectivity density related to cognitive impairment in alcoholics.Frontiers in psychology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsAutonomic dysfunction has been associated with risky drinking and alcohol use disorder (AUD). Although autonomic nervous system (ANS) activity has been attributed to the ventromedial prefrontal cortex (VmPFC)-limbic-striatal regions, the specific role of ANS disruption in AUD and its association with these regions remain unclear. Using functional magnetic resonance imaging (fMRI) and concurrent electrocardiogram (ECG), the current study examined neural correlates of ANS activity in AUD and its role in AUD pathology.
methodsDemographically matched 20 AUD patients and 20 social drinkers (SD) completed an fMRI task involving repeated exposure to stress, alcohol-cue and neutral-relaxing images in a block design. Based on the known VmPFC-limbic-striatal functions involved in emotions, reward and the ANS, we performed a regions of interest (ROI) analysis to examine the associations between ANS activity and neural responses in the VmPFC, amygdala, and ventral striatum.
resultsAcross conditions, AUD patients showed significantly higher levels of overall heart rate (HR) and approximate entropy (ApEn) compared to SD (Ps < 0.05). In all participants, increased HR was associated with greater drinking volume (P < 0.05). In addition, higher ApEn levels were associated with greater drinking volume (P < 0.05) and decreased right VmPFC response to stress (P < 0.05). DISCUSSION: Our findings demonstrate ANS disruption in AUD indexed by high overall HR and ApEn. The association between ApEn and rVmPFC response suggests that ApEn may play a role in modulating drinking via interactions with neural regions of emotion regulation. These findings provide insight into patterns of ANS disruption and their relevance to AUD pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.