Evidence map›Paper›PMID 34491201›Full record

ArticleeLife2021

Distributed functions of prefrontal and parietal cortices during sequential categorical decisions.

Yang Zhou, Matthew C Rosen, Sruthi K Swaminathan, Nicolas Y Masse, Ou Zhu, David J Freedman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Posterior Parietal Cortex Plays a Causal Role in Abstract Memory-Based Visual Categorical Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  12. Article
  13. Article
  14. Abstract Encoding of Categorical Decisions in Medial Superior Temporal and Lateral Intraparietal Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  15. The Representational Dynamics of Sequential Perceptual Averaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yang Zhou *Department of Neurobiology, The University of Chicago, Chicago, United States.ORCID 0000-0002-4517-1052
Matthew C Rosen *Department of Neurobiology, The University of Chicago, Chicago, United States.ORCID 0000-0002-7868-1702
Sruthi K SwaminathanDepartment of Neurobiology, The University of Chicago, Chicago, United States.
Nicolas Y MasseDepartment of Neurobiology, The University of Chicago, Chicago, United States.ORCID 0000-0002-9094-1298
Ou ZhuDepartment of Neurobiology, The University of Chicago, Chicago, United States.ORCID 0000-0001-8785-8453
David J FreedmanDepartment of Neurobiology, The University of Chicago, Chicago, United States.ORCID 0000-0002-2485-5981
University of Chicago · USPeking University · CN

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Cortical Mechanisms of Visual Category Recognition and LearningR01EY019041 · NEI · UNIVERSITY OF CHICAGO · PI David J Freedman · 2009 to 2026
$8.5M
NEI NIH HHS R01 EY019041NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

Comparing sequential stimuli is crucial for guiding complex behaviors. To understand mechanisms underlying sequential decisions, we compared neuronal responses in the prefrontal cortex (PFC), the lateral intraparietal (LIP), and medial intraparietal (MIP) areas in monkeys trained to decide whether sequentially presented stimuli were from matching (M) or nonmatching (NM) categories. We found that PFC leads M/NM decisions, whereas LIP and MIP appear more involved in stimulus evaluation and motor planning, respectively. Compared to LIP, PFC showed greater nonlinear integration of currently visible and remembered stimuli, which correlated with the monkeys' M/NM decisions. Furthermore, multi-module recurrent networks trained on the same task exhibited key features of PFC and LIP encoding, including nonlinear integration in the PFC-like module, which was causally involved in the networks' decisions. Network analysis found that nonlinear units have stronger and more widespread connections with input, output, and within-area units, indicating putative circuit-level mechanisms for sequential decisions.

Indexed as

AnimalsBehavior, AnimalMacaca mulattaMaleNeuronsParietal LobePrefrontal Cortexcategorizationdelayed match to samplemixed selectivityneuroscienceparietalprefrontalrecurrent neural networkrhesus macaque

Identifiers

PMID34491201
PMCPMC8423442
OpenAlexW3194485316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.