Evidence map›Paper›PMID 34491127›Full record

ReviewRadiology2021

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage.

Majid Chalian, Xiaojuan Li, Ali Guermazi, Nancy A Obuchowski, John A Carrino, Edwin H Oei, Thomas M Link, RSNA QIBA MSK Biomarker Committee, SNA QIBA MSK Biomarker Committee Members

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Detection of Early Knee Osteoarthritis Using Multi-Component TJournal of magnetic resonance imaging : JMRI · 2026
    Article
  7. Article
  8. Posterior Horn Meniscus Centroid Position Is Altered Soon After Noncontact ACL Injury in Males and Females.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  9. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  10. Early Knee Osteoarthritis Detection by Multi-Component TBioengineering (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Exercise-Induced Changes in Knee Cartilage In Vivo: Comparing MRI Sequences.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  16. Article
  17. Article
  18. Sports Radiology: A Key Driver of Clinical Decision-Making.Diagnostics (Basel, Switzerland) · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Majid ChalianFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0001-8400-1593
Xiaojuan LiFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0002-0567-9935
Ali GuermaziFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0002-9374-8266
Nancy A ObuchowskiFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0003-1891-7477
John A CarrinoFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0003-3472-2469
Edwin H OeiFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0003-3727-3427
Thomas M LinkFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).ORCID 0000-0002-2850-8143
RSNA QIBA MSK Biomarker CommitteeFrom the Department of Radiology, Division of Musculoskeletal Imaging and Intervention, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105 (M.C.); Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI) (X.L.), and Department of Biostatistics (N.A.O.), Cleveland Clinic, Cleveland, Ohio; Department of Radiology, Boston University School of Medicine, Boston, Mass (A.G.); Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY (J.A.C.); Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands (E.H.O.); European Imaging Biomarkers Alliance (E.H.O.); and Department of Radiology and Biomedical Imaging, University of California, San Francisco, Calif (T.M.L.).
SNA QIBA MSK Biomarker Committee Members

Funding

Multi-Vendor Multi-Site Novel Accelerated MRI RelaxometryR01AR077452 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOJUAN · 2020 to 2025
$3.6M
NIAMS NIH HHS R01 AR077452
6 · The paper itself

Abstract

MRI-based cartilage compositional analysis shows biochemical and microstructural changes at early stages of osteoarthritis before changes become visible with structural MRI sequences and arthroscopy. This could help with early diagnosis, risk assessment, and treatment monitoring of osteoarthritis. Spin-lattice relaxation time constant in rotating frame (T1ρ) and T2 mapping are the MRI techniques best established for assessing cartilage composition. Only T2 mapping is currently commercially available, which is sensitive to water, collagen content, and orientation of collagen fibers, whereas T1ρ is more sensitive to proteoglycan content. Clinical application of cartilage compositional imaging is limited by high variability and suboptimal reproducibility of the biomarkers, which was the motivation for creating the Quantitative Imaging Biomarkers Alliance (QIBA) Profile for cartilage compositional imaging by the Musculoskeletal Biomarkers Committee of the QIBA. The profile aims at providing recommendations to improve reproducibility and to standardize cartilage compositional imaging. The QIBA Profile provides two complementary claims (summary statements of the technical performance of the quantitative imaging biomarkers that are being profiled) regarding the reproducibility of biomarkers. First, cartilage T1ρ and T2 values are measurable at 3.0-T MRI with a within-subject coefficient of variation of 4%-5%. Second, a measured increase or decrease in T1ρ and T2 of 14% or more indicates a minimum detectable change with 95% confidence. If only an increase in T1ρ and T2 values is expected (progressive cartilage degeneration), then an increase of 12% represents a minimum detectable change over time. The QIBA Profile provides recommendations for clinical researchers, clinicians, and industry scientists pertaining to image data acquisition, analysis, and interpretation and assessment procedures for T1ρ and T2 cartilage imaging and test-retest conformance. This special report aims to provide the rationale for the proposed claims, explain the content of the QIBA Profile, and highlight the future needs and developments for MRI-based cartilage compositional imaging for risk prediction, early diagnosis, and treatment monitoring of osteoarthritis.

Indexed as

Cartilage, ArticularHumansKneeMagnetic Resonance ImagingOsteoarthritis, KneeReproducibility of Results

Identifiers

PMID34491127
PMCPMC8574057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.