Evidence map›Paper›PMID 34491031›Full record

ArticleACS infectious diseases2021

Cyclic Tetrapeptide HDAC Inhibitors with Improved

Jennifer E Collins, Jin Woo Lee, Monica J Bohmer, Joshua D Welden, Arash K Arshadi, Lin Du, Robert H Cichewicz, Debopam Chakrabarti

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Molecular mechanisms involved inFrontiers in microbiology · 2026
    Review
  6. Article
  7. Fungal-derived methyldeoxaphomins targetProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Virtual Special Issue: Epigenetics 2022.ACS pharmacology & translational science · 2022
    Article
  14. Virtual Special Issue: Epigenetics 2022.ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jennifer E CollinsDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.ORCID 0000-0002-1195-4630
Jin Woo LeeDepartment of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.
Monica J BohmerDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.
Joshua D WeldenDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.
Arash K ArshadiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.
Lin DuDepartment of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.ORCID 0000-0001-8751-4482
Robert H CichewiczDepartment of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.ORCID 0000-0003-0744-4117
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.ORCID 0000-0002-4554-3119
University of Central Florida · USUniversity of Oklahoma · US

Funding

Novel Antimalarials from FungiR01AI154777 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2020 to 2024
$3.8M
Discovery of Novel Antimalarial Compounds from FungiR21AI143052 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2019 to 2020
$423k
NIAID NIH HHS R01 AI154777NIAID NIH HHS R21 AI143052
6 · The paper itself

Abstract

Cyclic tetrapeptide histone deacetylase inhibitors represent a promising class of antiplasmodial agents that epigenetically disrupt a wide range of cellular processes in

Indexed as

AntimalarialsPlasmodium falciparumAscomycotaHistone Deacetylase InhibitorsAntimalarialsHistone Deacetylase Inhibitorscyclic tetrapeptideHDACmalarianatural productsPfHDAC1Plasmodium

Identifiers

PMID34491031
PMCPMC8822587
OpenAlexW3198051777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.