Evidence map›Paper›PMID 34491004›Full record

ArticleBirth defects research2021

Clinical and neurodevelopmental outcomes based on brain imaging studies in a Colombian cohort of children with probable antenatal Zika virus exposure.

Marcela Daza, Marcela Mercado, Cynthia A Moore, Diana Valencia, Maria Fernanda Lengua, Suzanne Newton, Blanca Rodríguez, Van T Tong, Pedro Acevedo, Suzanne M Gilboa and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Clinical, Neuroimaging and Video Electroencephalography Findings in Children With Congenital Zika Syndrome: An Analysis From a Neurorehabilitation Centre.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Marcela DazaResearch Division, Vysnova Partners, Bethesda, Maryland, USA.
Marcela MercadoDivision of Research in Public Health, National Institute of Health of Colombia, Bogota, Colombia.
Cynthia A MooreDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0003-4224-2692
Diana ValenciaDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Maria Fernanda LenguaDepartment of Child Neurology, Hospital Naval, Cartagena, Colombia.
Suzanne NewtonDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Blanca RodríguezDivision of Health Sciences, School of Medicine, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia.
Van T TongDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Pedro AcevedoColombian Society of Pediatric Ophthalmology and Strabismus, Bogotá, Republic of Columbia, Colombia.
Suzanne M GilboaDivision of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Martha L OspinaNational Institute of Health, Bogota DC, Republic of Columbia, Colombia.
Sarah B MulkeyPrenatal Pediatrics Institute, Children's National Hospital, Washington, District of Columbia, USA.
Centers for Disease Control and Prevention · USChildren's National · USFederación Colombiana de Obstetricia y Ginecología · COMass General Brigham · USNational Institute of Health · AMPedagogical and Technological University of Colombia · COScience and Technology Corporation for Naval, Maritime and Riverine Industry Development · COUniversidad Nacional de Colombia · CO

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundOur aim was to describe the neuroimaging and clinical evaluations of children with antenatal Zika-virus (ZIKV) exposure.

methodsThe Colombian National Institute of Health performed serial clinical evaluations of children with probable antenatal ZIKV exposure (i.e., born to ZIKV symptomatic mothers or born with birth defects compatible with ZIKV infection, regardless of laboratory results) over 2 years that included head circumference (HC), eye examination, and neurodevelopmental assessments. Clinical neuroimaging studies (head computed tomography and/or brain magnetic resonance imaging) were analyzed for abnormalities, two-dimensional measurements were made of the right and left frontal and occipital cortical thickness. Two abnormal patterns were defined: Pattern 1 (sum of four areas of cortex <6 cm) and Pattern 2 (sum of four areas of cortex ≥6 cm and < 10 cm).

resultsThirty-one children had a neuroimaging study; in 24, cortical thickness was measured. The median age at the first visit was 8 (range: 6-9) months and 22 (range: 19-42) months at the last evaluation. In the 24 cases with cortical measurements, three were normal, 12 were in Pattern 1, and nine were in Pattern 2. Children within Pattern 1 had lower mean HC at birth and in follow-up (both p < .05) and a higher frequency of structural eye abnormalities (p < .01). A trend towards poorer neuromotor development was seen in Pattern 1, although not statistically significant (p = .06).

conclusionBrain imaging classification based on cortical measurements correlate with ophthalmologic abnormalities and HC. Cortical thickness may be a marker for clinical outcomes in children with congenital ZIKV infection.

Indexed as

MicrocephalyPregnancy Complications, InfectiousZika VirusZika Virus InfectionBrainChildColombiaFemaleHumansInfant, NewbornNeuroimagingPregnancycongenital abnormalitiesdevelopmental disabilitieseye abnormalitiesmicrocephalyneuroimaging

Identifiers

PMID34491004
PMCPMC10535366
OpenAlexW3198513367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.