Evidence map›Paper›PMID 34490982›Full record

ArticlePediatric blood & cancer2022

Hodgkin lymphoma in an individual with TREX1-mediated Aicardi Goutières syndrome.

Francesco Gavazzi, Jamie L Fraser, Miriam Bloom, Laura Tochen, Jullie Rhee, Megan Kwan, Teresa Victoria, David T Teachey, Cheng-Ying Ho, Adeline Vanderver and 1 more

Open access · greenAbstract readCase ReportsLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Rigorous genetic diagnosis review in natural history studies.Orphanet journal of rare diseases · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Francesco GavazziDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4908-8395
Jamie L FraserRare Disease Institute, Division of Genetics and Metabolism, Children's National Hospital, Washington, District of Columbia, USA.
Miriam BloomDepartment of Pediatrics, Children's National Hospital, Washington, District of Columbia, USA.
Laura TochenDepartment of Neurology, Children's National Hospital, Washington, District of Columbia, USA.
Jullie RheeDepartment of Neurology, Children's National Hospital, Washington, District of Columbia, USA.
Megan KwanDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Teresa VictoriaDivision of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
David T TeacheyDivisions of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Cheng-Ying HoDepartment of Pathology and Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Adeline VanderverDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rebecca L LinnDepartment of Pathology and Lab Medicine at Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Children's Hospital of Philadelphia · USChildren's National · USUniversity of Maryland, Baltimore · US

Funding

Validation of the GMFC-MLDU54NS115052 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Adeline Lucie Vanderver · 2019 to 2026
$14.3M
Clinical Outcomes in Aicardi Goutières SyndromeU01NS106845 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI VANDERVER, ADELINE LUCIE · 2019 to 2023
$7.5M
The role of skin BDNF in the maintenance of the cutaneous mechanosensory nervous systemK08NS102468 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HO, CHENG-YING · 2018 to 2022
$1.0M
NINDS NIH HHS K08 NS102468NINDS NIH HHS U01 NS106845NINDS NIH HHS U54 NS115052
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Autoimmune Diseases of the Nervous SystemExodeoxyribonucleasesHodgkin DiseaseNervous System MalformationsPhosphoproteinsHumansMutationExodeoxyribonucleasesPhosphoproteinsthree prime repair exonuclease 1

Identifiers

PMID34490982
PMCPMC11348674
OpenAlexW3197855328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.