Evidence map›Paper›PMID 34490838›Full record

ArticleExpert review of hematology2021

Strategies to improve pharmacogenomic-guided treatment options for patients with β-hemoglobinopathies.

George P Patrinos, David H K Chui, Ross C Hardison, Martin H Steinberg

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert review of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Role ofLife (Basel, Switzerland) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

George P PatrinosSchool of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, University of Patras, Patras, Greece.ORCID 0000-0002-0519-7776
David H K ChuiDepartments of Medicine, Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Ross C HardisonCenter for Computational Biology and Bioinformatics, The Pennsylvania State University, University Park, PA, USA.
Martin H SteinbergDepartments of Medicine, Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1M
Transcriptional Networks Controlling Erythroid DifferentiationR01DK054937 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 1999 to 2026
$12.8M
Genomic Architecture of LGL LeukemiaR01CA178393 · NCI · UNIVERSITY OF VIRGINIA · PI Thomas P. Loughran, Aakrosh Ratan · 2016 to 2026
$6.5M
VISION: ValIdated Systematic IntegratiON of epigenomic dataR24DK106766 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI BLOBEL, GERD A, BODINE, DAVID M. · 2016 to 2020
$6.2M
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA178393NIDDK NIH HHS R01 DK054937NIDDK NIH HHS R24 DK106766
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle Cellbeta-ThalassemiaHemoglobinopathiesHumansHydroxyureaPharmacogeneticsHydroxyureaclinical trialsgenomic variantspharmacogenomicssickle cell diseasetherapeuticsβ-hemoglobinopathies

Identifiers

PMID34490838
PMCPMC9306350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.