ArticlePediatric nephrology (Berlin, Germany)2021
The effect of levamisole on kidney function in children with steroid-sensitive nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Daily compared with alternate-day levamisole in pediatric nephrotic syndrome: an open-label randomized controlled study.Pediatric nephrology (Berlin, Germany) · 2024Trial
- Levamisole causes a transient increase in plasma creatinine levels but does not affect kidney function based on cystatin C.Pediatric nephrology (Berlin, Germany) · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundLevamisole is frequently used as a steroid-sparing agent in children with steroid-sensitive nephrotic syndrome. Side effects, such as neutropenia, gastro-intestinal upset and skin rash, have been reported. We noted an increase in creatinine in some of our patients, but literature on the effect of levamisole on kidney function is lacking.
methodsA retrospective cohort study was conducted, including patients 1-18 years of age, treated for steroid-sensitive nephrotic syndrome with levamisole at Great Ormond Street Hospital for Children between January 2010 and January 2020. Data was collected on clinical observations and serum creatinine values before, during and after treatment. eGFR was calculated using the Schwartz equation.
resultsIn total, 75 children were included in the analysis. The median duration of treatment was 19 (IQR 12-27) months. The median estimated GFR was 134 (IQR 119-160), 101 (IQR 91-113) and 116 (IQR 106-153) ml/min/1.73 m
conclusionLevamisole significantly decreases eGFR. However, this decrease is not progressive or irreversible and would not be an indication to discontinue the treatment.
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