Evidence map›Paper›PMID 34490493›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2021

Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [

Zhicong Li, Lena Kaiser, Adrien Holzgreve, Viktoria C Ruf, Bogdana Suchorska, Vera Wenter, Stefanie Quach, Jochen Herms, Peter Bartenstein, Jörg-Christian Tonn and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. [Journal of neuro-oncology · 2026
    Article
  3. Integrating clinical features withBMC medical imaging · 2025
    Article
  4. Article
  5. Radiomics in glioma: emerging trends and challenges.Annals of clinical and translational neurology · 2025
    Review
  6. Pre-operative dual-time-point [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Prediction of Glioma Grade and IDH Status UsingDiagnostics (Basel, Switzerland) · 2023
    Article
  14. Review
  15. Review
  16. Feasibility of radiomic feature harmonization for pooling of [Zeitschrift fur medizinische Physik · 2023
    Article
  17. Combination of pre-treatment dynamic [European journal of nuclear medicine and molecular imaging · 2023
    Article
  18. Quantitative imaging in medicine and surgery · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhicong LiDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Lena KaiserDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Adrien HolzgreveDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Viktoria C RufCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Bogdana SuchorskaDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.
Vera WenterDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Stefanie QuachDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.
Jochen HermsCenter for Neuropathology and Prion Research, LMU Munich, Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Jörg-Christian TonnDepartment of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.
Marcus UnterrainerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany. nathalie.albert@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate radiomic features extracted from standard static images (20-40 min p.i.), early summation images (5-15 min p.i.), and dynamic [

methodsA total of 159 patients (median age 60.2 years, range 19-82 years) with newly diagnosed IDH-wildtype diffuse astrocytic glioma (WHO grade III or IV) and dynamic [

resultsThe TTP model comprised nine selected features and achieved highest predictability of TERTp-mutation with an AUC of 0.82 (95% confidence interval 0.71-0.92) and sensitivity of 92.1% in the independent testing cohort. Weak predictive capability was obtained in the TBR

conclusionsRadiomics based on TTP images extracted from dynamic [

Indexed as

Brain NeoplasmsGliomaAdultAgedAged, 80 and overHumansIsocitrate DehydrogenaseMiddle AgedMutationPositron-Emission TomographyRetrospective StudiesYoung AdultIsocitrate Dehydrogenase[18F]FET PETGliomaRadiomicsTERTp-mutation

Identifiers

PMID34490493
PMCPMC8566644
OpenAlexW3196539054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.