ArticleFrontiers in cardiovascular medicine2021
Preclinical Testing of Living Tissue-Engineered Heart Valves for Pediatric Patients, Challenges and Opportunities.
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In one paragraph
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Long-Term Effects of Right Ventricular Pressure and Volume Overload: A Comparative Analysis in an Ovine Model.Journal of clinical medicine · 2026Article
- Innovative Sutureless Fabrication Strategy for Tissue-Engineered Pediatric Heart Valves Using an Evolutive Support System.Annals of biomedical engineering · 2026Article
- The PEDIAVALVE project - tissue-engineered pulmonary valves for paediatric valvular replacement.Frontiers in bioengineering and biotechnology · 2026Article
- The "Cairo Accord"- towards the eradication of RHD: revisited (2026).Frontiers in cardiovascular medicine · 2026Review
- Short- and Medium-Term Surgical Outcomes of Tissue-Engineered Pulmonary Valve Replacement in Sheep.Tissue engineering and regenerative medicine · 2025Article
- Mechanistic Insights into Bioprosthetic Heart Valve Calcification and Anti-Calcification Strategies.Reviews in cardiovascular medicine · 2025Review
- The Relationship Between Motivation for Physical Activity, Physical Activity Level, and Body Mass Index for University Students.Sports (Basel, Switzerland) · 2025Article
- Article
- A chronological history of heart valve prostheses to offer perspectives of their limitations.Frontiers in bioengineering and biotechnology · 2025Review
- The path to a hemocompatible cardiovascular implant: Advances and challenges of current endothelialization strategies.Frontiers in cardiovascular medicine · 2022Review
- Stem cell-derived extracellular vesicles reduce the expression of molecules involved in cardiac hypertrophy-In a model of human-induced pluripotent stem cell-derived cardiomyocytes.Frontiers in pharmacology · 2022Article
- Future prospects in the tissue engineering of heart valves: a focus on the role of stem cells.Expert opinion on biological therapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 3 countries.
Ionela MovileanuRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Marius HarpaRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Hussam Al HusseinRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Lucian HarceagaRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Alexandru ChertesRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Hamida Al HusseinRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Georg LutterDepartment for Experimental Cardiac Surgery and Heart Valve Replacement, School of Medicine, University of Kiel, Kiel, Germany.
Thomas PuehlerDepartment for Experimental Cardiac Surgery and Heart Valve Replacement, School of Medicine, University of Kiel, Kiel, Germany.
Terezia PredaRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Carmen SircutaRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Ovidiu CotoiRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Dan NistorRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Adrian ManRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Bogdan CordosRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Radu DeacRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Horatiu SuciuRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Klara BrinzaniucRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Megan CascoBiocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, Clemson, SC, United States.
Leslie SieradAptus Bioreactors, LLC, Clemson, SC, United States.
Margarita BruceBiocompatibility and Tissue Regeneration Laboratory, Department of Bioengineering, Clemson University, Clemson, SC, United States.
Dan SimionescuRegenerative Medicine Laboratory, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", Târgu Mureş, Romania.
Agneta SimionescuTissue Engineering Laboratory, Department of Bioengineering, Clemson University, Clemson, SC, United States.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROBiocom · USKiel University · DEClemson University · USUS Biologic (United States) · US
Funding
Transnational Research Imaging Core (TRI)P30GM131959 · NIGMS · CLEMSON UNIVERSITY · PI VYAVAHARE, NAREN R · 2019 to 2023
$5.9MCell and matrix interactions in diabetic vascular tissue engineering modelsR01HL133303 · NHLBI · CLEMSON UNIVERSITY · PI SIMIONESCU, AGNETA · 2018 to 2021
$1.4MNHLBI NIH HHS R01 HL133303NIGMS NIH HHS P30 GM131959
Abstract
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Indexed as
acellular scaffoldsautologous cellsbioreactor conditioningcell seedingorthotopic implantation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.