Evidence map›Paper›PMID 34490246›Full record

ArticleFrontiers in cell and developmental biology2021

Loss of PIKfyve Causes Transdifferentiation of

Yoko Yamada, Gillian Forbes, Qingyou Du, Takefumi Kawata, Pauline Schaap

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yoko YamadaSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
Gillian ForbesSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
Qingyou DuSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
Takefumi KawataDepartment of Biology, Faculty of Science, Toho University, Funabashi, Japan.
Pauline SchaapSchool of Life Sciences, University of Dundee, Dundee, United Kingdom.
University of Dundee · GBToho University · JP

Funding

Biotechnology and Biological Sciences Research Council BB/D013453/1Biotechnology and Biological Sciences Research Council BB/G020426/1
6 · The paper itself

Abstract

The 1-phosphatidylinositol-3-phosphate 5-kinase PIKfyve generates PtdIns3,5P2 on late phagolysosomes, which by recruiting the scission protein Atg18, results in their fragmentation in the normal course of endosome processing. Loss of PIKfyve function causes cellular hypervacuolization in eukaryotes and organ failure in humans. We identified

Indexed as

1-phosphatidylinositol-3-phosphate 5-kinaseAtg18cell-type specific gene expressionDictyosteliummembrane scissionsporulationVac14vesicle trafficking

Identifiers

PMID34490246
PMCPMC8417116
OpenAlexW3193296008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.