Evidence map›Paper›PMID 34490143›Full record

ArticleFrontiers in cellular and infection microbiology2021

Time to Detection of Growth for

Rechana Vongthilath-Moeung, Antoine Poncet, Gesuele Renzi, Jacques Schrenzel, Jean-Paul Janssens

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cell-free DNA blood test for the diagnosis of pediatric tuberculous meningitis.Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Utility of anti-Heliyon · 2022
    Article
  11. Tuberculosis in pregnancy.Best practice & research. Clinical obstetrics & gynaecology · 2022
    Review
  12. Making cough count in tuberculosis care.Communications medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rechana Vongthilath-MoeungDivision of Pulmonary Diseases, Geneva University Hospitals, Geneva, Switzerland.
Antoine PoncetCenter for Clinical Research & Division of Clinical-Epidemiology, Department of Health and Community Medicine, University of Geneva, University Hospitals of Geneva, Geneva, Switzerland.
Gesuele RenziBacteriology Laboratory, Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
Jacques SchrenzelBacteriology Laboratory, Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
Jean-Paul JanssensDivision of Pulmonary Diseases, Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diagnosis of Objectives: To determine TDG in Xpert negative samples, or in samples in which Xpert could not be performed, in a low-incidence area for MTB. Methods: Retrospective analysis (2015-2020) of a database including all cultures for mycobacteria in a University Hospital covering approximately 500'000 inhabitants. Analysis was restricted to culture positive (C+) samples for MTB for which 1/Xpert was negative or could not be performed because of limited sample volume, and 2/collected from subjects treated less than 24 hours. TDG was analyzed according to microscopy, origin of sample (pulmonary or not) and presence of cavitation. Results: Among 837 C+ samples for MTB, 236 samples (80% of respiratory origin) from 147 patients fulfilled study criteria; 78 samples (49 patients, 33%) were acid-fast bacilli (AFB) positive. Median (IQR) TDG was 25 (17; 40) days for all samples. TDG exceeded 28 days in 43% of samples and was significantly shorter in AFB+ Conclusions: In Xpert negative samples, or samples for which Xpert could not be performed, TDG exceeded 4 weeks in 43% of samples. AFB+ and samples from cavitary lung disease had a significantly shorter TDG.

Indexed as

Mycobacterium tuberculosisTuberculosis, PulmonaryHumansIncidenceRetrospective StudiesRifampinSensitivity and SpecificitySputumRifampinmycobacteriamycobacterium growth indicator tubeMycobacterium tuberculosisnuclear acid amplification techniquestime to detection of growth

Identifiers

PMID34490143
PMCPMC8418320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.