Evidence map›Paper›PMID 34490136›Full record

ArticleFrontiers in cellular and infection microbiology2021

Characterization of Vaginal Microbiota in Women With Recurrent Spontaneous Abortion That Can Be Modified by Drug Treatment.

Fuju Zhao, Yisheng Chen, Jing Gao, Mengyin Wu, Cui Li, Zhiheng Wang, Nali Huang, Lefang Cui, Meirong Du, Chunmei Ying

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. VaginalFrontiers in cellular and infection microbiology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. IntratumorCurrent research in microbial sciences · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Microbiome Changes in Pregnancy Disorders.Antioxidants (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Fuju ZhaoClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Yisheng ChenClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Jing GaoClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Mengyin WuKey Laboratory of Medical Molecular Virology of the Ministry of Education/Ministry of Health (MOE/MOH), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Cui LiClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Zhiheng WangClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Nali HuangSinotech Genomics Co., Ltd., Shanghai, China.
Lefang CuiSinotech Genomics Co., Ltd., Shanghai, China.
Meirong DuNHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University Shanghai Medical College, Shanghai, China.
Chunmei YingClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Obstetrics and Gynecology Hospital of Fudan University · CNFudan University · CNSinotech Genomics (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The role of vaginal microbiota in recurrent spontaneous abortion (RSA) remains unknown. The purpose of this study was to investigate characteristics of vaginal microbiota and the effects of drug treatment on vaginal microbiota of patients with RSA. Methods: A case-control study was performed, in which non-pregnant patients who experienced RSA were selected and divided into untreated and drug-treated groups. Drug-treated patients were subdivided into the metformin group, metformin plus aspirin group, and other drugs group. Healthy women who had live births and never experienced spontaneous abortion were enrolled in the control group. Characteristics of vaginal microbiomes of patients with RSA and healthy women and the impact of drug treatment on the microbiome was evaluated Results: Women who underwent RSA had lower microbial richness than healthy women. Compared to controls, the relative abundance of seven taxa ( Conclusion: An altered vaginal microbiome composition might be associated with RSA, which could be modified by drug treatment. The effect of metformin combined with aspirin on vaginal

Indexed as

Abortion, SpontaneousMicrobiotaPharmaceutical PreparationsCase-Control StudiesFemaleFusobacteriaHumansPregnancyRNA, Ribosomal, 16SVaginaPharmaceutical PreparationsRNA, Ribosomal, 16S16S rRNA geneaspirinmetforminrecurrent spontaneous abortionRSAvaginal microbiome

Identifiers

PMID34490136
PMCPMC8417370
OpenAlexW3195756134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.