ArticleFrontiers in oncology2021
Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Analysis of clinicopathological features, treatment modalities, and survival outcomes in advanced gastric and colorectal signet ring cell carcinoma.Discover oncology · 2025Article
- A prognostic nomogram utilized lymph node ratio for signet ring cell gastric cancer patients post-surgery.Journal of gastrointestinal oncology · 2025Article
- Development and validation of a tumor size-stratified prognostic nomogram for patients with gastric signet ring cell carcinoma.Updates in surgery · 2024Article
- Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma.World journal of clinical oncology · 2024Article
- Diagnostic value of dual-source, dual-energy computed tomography combined with the neutrophil-lymphocyte ratio for discriminating gastric signet ring cell from mixed signet ring cell and non-signet ring cell carcinomas.Abdominal radiology (New York) · 2024Article
- Lifestyle factors on the long-term survival of gastric cancer patients after radical resection: A cohort study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis.Cancers · 2023Review
- The percentages of signet-ring cells (SRCs) affects the prognosis after radical gastrectomy for advanced gastric cancer.Langenbeck's archives of surgery · 2023Article
- Article
- Comprehensive Analysis of Clinicopathological and Molecular Features to Predict Anti-PD-1-Based Therapy Efficacy in Patients with Advanced Gastric Signet Ring Cell Carcinoma.Journal of personalized medicine · 2023Article
- Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period.Frontiers in oncology · 2023Article
- Clinicopathological characteristics and prognosis of gastric signet ring cell carcinoma.World journal of clinical cases · 2022Article
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11 authors.
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Abstract
backgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.
methodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to estimate Overall survival (OS) and to determine associations with histologic subtypes. In COX proportional hazards regression model-based univariate and multivariate analyses, significant variables for construction of a nomogram were screened out. The nomogram was validated by means of the concordance index (CI), calibration plots, and receiver operating characteristics (ROCs) curves.
resultsA total of 11,363 gastric cancer patients were enrolled. On dividing the patients into SRC, well-to-moderately differentiated (WMD) adenocarcinoma, and poorly differentiated (PD) adenocarcinoma, differences among these subgroups emerged. SRC patients were more likely to occur in female and young patients than other histologic subtypes. Larger tumors, stage T4, and node stage N3 were more likely to be found in the SRC group. The survival for SRC patients was better than non-SRC patients in stage I. Univariate and multivariate analyses identified age, tumor site, larger tumor size, advanced T classification, advanced N classification, advanced TNM stage, and surgery of primary site as independent prognostic indicators. Then an OS nomogram was formulated.
conclusionsSRC had distinct clinicopathological characteristics. The nomogram provided an accurate tool to evaluate the prognosis of SRC.
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