Evidence map›Paper›PMID 34490035›Full record

ArticleFrontiers in genetics2021

The Interaction of Single Nucleotide Polymorphisms on Fibroblast Growth Factor 19 Superfamily Genes Is Associated With Alcohol Dependence-Related Aggression.

Jinzhong Xu, Fenzan Wu, Fan Wang, Fan Yang, Meng Liu, Mengbei Lou, Linman Wu, Hui Li, Wenhui Lin, Yunchao Fan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jinzhong XuDepartment of Clinical Pharmacy, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, China.
Fenzan WuLaboratory of Translational Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, China.
Fan WangPsychiatry Research Center, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Fan YangSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Meng LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Mengbei LouSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Linman WuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Hui LiXinjiang Key Laboratory of Neurological Disorder Research, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
Wenhui LinDepartment of Cardiovascular Medicine, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, China.
Yunchao FanDepartment of Cardiovascular Medicine, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, China.
Li ChenSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Yanlong LiuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Haiyun XuSchool of Mental Health, Wenzhou Medical University, Wenzhou, China.
Jue HeThe Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNJinzhou Kangning Hospital · CNBeijing HuiLongGuan Hospital · CNSecond Affiliated Hospital of Xinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol dependence (AD) is characterized by compulsive alcohol consumption, which involves behavioral impairments such as aggression. Members of fibroblast growth factor (FGF) 19 superfamily, including FGF19, FGF21, and FGF23, are major endocrine mediators that play an important role in alcohol metabolism and alcohol related disorders. The objective of the present study is to explore the possible associations among the interaction of single nucleotide polymorphisms (SNPs) of the FGF 19 superfamily, AD occurrence, and aggression in patients with AD. A total of 956 subjects were enrolled in this study, including 482 AD patients and 474 healthy controls (HCs). Michigan alcoholism screening test (MAST) was used to measure the level of AD, a Chinese version of the Buss-Perry Aggression Questionnaire was used to evaluate the aggressive behavior of subjects, and MassARRAY

Indexed as

aggressionalcohol dependenceFGF19FGF21FGF23single nucleotide polymorphism

Identifiers

PMID34490035
PMCPMC8416495
OpenAlexW3193872770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.