Evidence map›Paper›PMID 34489939›Full record

ArticleFrontiers in immunology2021

The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis.

Chiara Agostinis, Sonia Zorzet, Andrea Balduit, Gabriella Zito, Alessandro Mangogna, Paolo Macor, Federico Romano, Miriam Toffoli, Beatrice Belmonte, Gaia Morello and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. The role ofFrontiers in immunology · 2026
    Article
  7. Review
  8. Article
  9. Endometriosis and autoimmunity.Autoimmunity reviews · 2025
    Review
  10. Article
  11. Review
  12. Impact of gut microbiota on endometriosis: linking physical injury to mental health.Frontiers in cellular and infection microbiology · 2025
    Review
  13. Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chiara AgostinisInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Sonia ZorzetDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Andrea BalduitDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Gabriella ZitoInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Alessandro MangognaInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Paolo MacorDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Federico RomanoInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Miriam ToffoliInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Beatrice BelmonteTumor Immunology Unit, Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy.
Gaia MorelloTumor Immunology Unit, Human Pathology Section, Department of Health Sciences, University of Palermo, Palermo, Italy.
Anna MartoranaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Violetta BorelliDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Giuseppe RicciInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Uday KishoreBiosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Roberta BullaDepartment of Life Sciences, University of Trieste, Trieste, Italy.
University of Trieste · ITIRCCS Materno Infantile Burlo Garofolo · ITUniversity of Palermo · ITBrunel University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes

Indexed as

Cell DegranulationAnimalsCase-Control StudiesCoculture TechniquesComplement C3Complement C3aDisease Models, AnimalEndometriosisEndometriumFemaleHep G2 CellsHumansImmunity, HumoralImmunity, InnateInflammation MediatorsMast CellsC3 protein, humanC3 protein, mouseComplement C3Complement C3aInflammation MediatorsTumor Necrosis Factor-alphaC3complement systemendometriosismast cellsTNF-α

Identifiers

PMID34489939
PMCPMC8418148
OpenAlexW3195381101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.