Evidence map›Paper›PMID 34489927›Full record

ArticleFrontiers in immunology2021

Combining Immunocytokine and

Paul D Bates, Alexander L Rakhmilevich, Monica M Cho, Myriam N Bouchlaka, Seema L Rao, Joanna M Hales, Rimas J Orentas, Terry J Fry, Stephen D Gilles, Paul M Sondel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The immune landscape of solid pediatric tumors.Journal of experimental & clinical cancer research : CR · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Paul D BatesDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Alexander L RakhmilevichDepartment of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Monica M ChoDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Myriam N BouchlakaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Seema L RaoDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Joanna M HalesPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Rimas J OrentasDepartment of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.
Terry J FryPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Stephen D GillesProvenance Biopharmaceuticals, Carlisle, MA, United States.
Paul M SondelDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Christian M CapitiniDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
University of Wisconsin–Madison · USUniversity of Wisconsin Carbone Cancer Center · USCenter for Cancer Research · USNational Cancer Institute · USUniversity of Washington · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Training in Cancer Biology Training GrantT32CA009135 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SUGDEN, WILLIAM M. · 1985 to 2024
$10.4M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Enhancing Antibody-directed Innate Immunity to Improve Cancer OutcomeR35CA197078 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 2015 to 2021
$6.4M
Combining hu14.18-IL2 and NK cell infusions to treat neuroblastomaR01CA215461 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAPITINI, CHRISTIAN · 2018 to 2022
$1.7M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA215461NCI NIH HHS R35 CA197078NCI NIH HHS T32 CA009135NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Management for high-risk neuroblastoma (NBL) has included autologous hematopoietic stem cell transplant (HSCT) and anti-GD2 immunotherapy, but survival remains around 50%. The aim of this study was to determine if allogeneic HSCT could serve as a platform for inducing a graft-versus-tumor (GVT) effect against NBL with combination immunocytokine and NK cells in a murine model. Lethally irradiated C57BL/6 (B6) x A/J recipients were transplanted with B6 bone marrow on Day +0. On day +10, allogeneic HSCT recipients were challenged with NXS2, a GD2

Indexed as

Graft vs Tumor EffectHematopoietic Stem Cell TransplantationImmunotherapy, AdoptiveAnimalsAntineoplastic Agents, ImmunologicalCell Line, TumorCombined Modality TherapyCytokinesFemaleGangliosidesKiller Cells, NaturalLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicAntineoplastic Agents, ImmunologicalCytokinesganglioside, GD2Gangliosidescytokine release syndromegraft-versus-tumor effectimmunocytokineneuroblastomaNK cells

Identifiers

PMID34489927
PMCPMC8417312
OpenAlexW3194003352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.