Evidence map›Paper›PMID 34489889›Full record

ArticleFrontiers in microbiology2021

Antibiotic Breakdown by Susceptible Bacteria Enhances the Establishment of β-Lactam Resistant Mutants.

Manja Saebelfeld, Suman G Das, Jorn Brink, Arno Hagenbeek, Joachim Krug, J Arjan G M de Visser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Contributions of intra- and extracellular antibiotic degradation to collective [Formula: see text]-lactam survival.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Stochastic establishment of β-lactam-resistantProceedings. Biological sciences · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manja SaebelfeldInstitute for Biological Physics, University of Cologne, Cologne, Germany.
Suman G DasInstitute for Biological Physics, University of Cologne, Cologne, Germany.
Jorn BrinkLaboratory of Genetics, Department of the Plant Sciences Group, Wageningen University and Research, Wageningen, Netherlands.
Arno HagenbeekLaboratory of Genetics, Department of the Plant Sciences Group, Wageningen University and Research, Wageningen, Netherlands.
Joachim KrugInstitute for Biological Physics, University of Cologne, Cologne, Germany.
J Arjan G M de VisserLaboratory of Genetics, Department of the Plant Sciences Group, Wageningen University and Research, Wageningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For a better understanding of the evolution of antibiotic resistance, it is imperative to study the factors that determine the initial establishment of mutant resistance alleles. In addition to the antibiotic concentration, the establishment of resistance alleles may be affected by interactions with the surrounding susceptible cells from which they derive, for instance

Indexed as

Escherichia colimutant establishmentresistance evolutionsocial interactionsβ-lactamase

Identifiers

PMID34489889
PMCPMC8417073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.