Evidence map›Paper›PMID 34489873›Full record

ArticleFrontiers in endocrinology2021

Case Report: Consecutive Adrenal Cushing's Syndrome and Cushing's Disease in a Patient With Somatic

Mario Detomas, Barbara Altieri, Wiebke Schlötelburg, Silke Appenzeller, Sven Schlaffer, Roland Coras, Andreas Schirbel, Vanessa Wild, Matthias Kroiss, Silviu Sbiera and 2 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mario DetomasDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Barbara AltieriDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Wiebke SchlötelburgDepartment of Diagnostic and Interventional Radiology, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Silke AppenzellerCore Unit Bioinformatics, Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, University of Würzburg, Würzburg, Germany.
Sven SchlafferDepartment of Neurosurgery, University Hospital Erlangen, Erlangen, Germany.
Roland CorasDepartment of Neuropathology, University Hospital Erlangen, Erlangen, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Vanessa WildInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Matthias KroissDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Silviu SbieraDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Martin FassnachtDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Timo DeutschbeinDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEUniversity of Würzburg · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of different subtypes of endogenous Cushing's syndrome (CS) in single individuals is extremely rare. We here present the case of a female patient who was successfully cured from adrenal CS 4 years before being diagnosed with Cushing's disease (CD). The patient was diagnosed at the age of 50 with ACTH-independent CS and a left-sided adrenal adenoma, in January 2015. After adrenalectomy and histopathological confirmation of a cortisol-producing adrenocortical adenoma, biochemical hypercortisolism and clinical symptoms significantly improved. However, starting from 2018, the patient again developed signs and symptoms of recurrent CS. Subsequent biochemical and radiological workup suggested the presence of ACTH-dependent CS along with a pituitary microadenoma. The patient underwent successful transsphenoidal adenomectomy, and both postoperative adrenal insufficiency and histopathological workup confirmed the diagnosis of CD. Exome sequencing excluded a causative germline mutation but showed somatic mutations of the β-catenin protein gene (

Indexed as

AdenomaAdrenal Cortex NeoplasmsAdrenalectomybeta CateninCushing SyndromeEndopeptidasesEndosomal Sorting Complexes Required for TransportFemaleGermanyHumansMiddle AgedMutationPituitary ACTH HypersecretionReceptors, GlucocorticoidUbiquitin Thiolesterasebeta CateninCTNNB1 protein, humanEndopeptidasesEndosomal Sorting Complexes Required for TransportNR3C1 protein, humanReceptors, GlucocorticoidUbiquitin ThiolesteraseUSP8 protein, humanCTNNB1Cushing’s diseaseCushing’s syndromeglucocorticoid excesshypercortisolismNR3C1USP8

Identifiers

PMID34489873
PMCPMC8417750
OpenAlexW3193390896

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.