Evidence map›Paper›PMID 34489870›Full record

ReviewFrontiers in endocrinology2021

Crash Landing of Thyroid Storm: A Case Report and Review of the Role of Extra-Corporeal Systems.

Shir Lynn Lim, Kangjie Wang, Pak Ling Lui, Kollengode Ramanathan, Samantha Peiling Yang

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shir Lynn LimDepartment of Cardiology, National University Heart Center, Singapore, Singapore.
Kangjie WangDivision of Endocrinology, Department of Medicine, National University Hospital, Singapore, Singapore.
Pak Ling LuiDepartment of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Kollengode RamanathanCardiothoracic Intensive Care Unit, National University Heart Center, Singapore, Singapore.
Samantha Peiling YangDivision of Endocrinology, Department of Medicine, National University Hospital, Singapore, Singapore.
National University Heart Centre Singapore · SGNational University Hospital · SGNational University Cancer Institute, Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid storm is a rare but life-threatening endocrinological emergency with significant mortality ranging from 10-30% with multi-organ involvement and failure. In view of the rarity of this condition and efficacy of established first line medical treatment, use of extra-corporeal treatments are uncommon, not well-studied, and its available evidence exists only from case reports and case series. We describe a 28-year-old man who presented with an out-of-hospital cardiac arrest secondary to thyroid storm. Despite conventional first-line pharmacotherapy, he developed cardiogenic shock and circulatory collapse with intravenous esmolol infusion, as well as multi-organ failure. He required therapeutic plasma exchange, concurrent renal replacement therapy, and veno-arterial extra-corporeal membrane oxygenation, one of the few reported cases in the literature. While there was clinical stabilization and improvement in tri-iodothyronine levels on three extra-corporeal systems, he suffered irreversible hypoxic-ischemic brain injury. We reviewed the use of early therapeutic plasma exchange and extra-corporeal membrane oxygenation, as well as the development of other novel extra-corporeal modalities when conventional pharmacotherapy is unsuccessful or contraindicated. This case also highlights the complexities in the management of thyroid storm, calling for caution with beta-blockade use in thyrocardiac disease, with close monitoring and prompt organ support.

Indexed as

AdultExtracorporeal Membrane OxygenationHumansMalePrognosisShock, CardiogenicThyroid Crisiscontinuous renal replacement therapyextra-corporeal membrane oxygenationmulti-organ failureout-of-hospital cardiac arresttherapeutic plasma exchangethyroid storm

Identifiers

PMID34489870
PMCPMC8417732
OpenAlexW3194447076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.