ReviewFrontiers in human neuroscience2021
Progress of Acupuncture Therapy in Diseases Based on Magnetic Resonance Image Studies: A Literature Review.
Review in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Functional brain alterations associated with acupuncture for chronic pain: a scoping review of fMRI studies.Frontiers in neuroscience · 2026Pooled it
- Combination treatment with acupoint therapy and conventional medication for non-motor symptoms in Parkinson's disease: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Acupuncture for migraine: a literature review of neuroimaging studies.Frontiers in neurology · 2025Pooled it
- Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache: A Secondary Analysis of A Randomized Controlled Trial.Chinese journal of integrative medicine · 2024Trial
- Acupuncture Alters Brain's Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial.Neural plasticity · 2023Trial
- Acupuncture as a potential host-directed therapeutic strategy in neuroinfectious diseases: a neuroimmune mechanistic perspective.Frontiers in medicine · 2026Article
- Stimulation of High-Conductivity Points in Human Skin Reduces Biotin Levels to Modulate Intracellular Metabolism and Local Energy Production.Health science reports · 2025Article
- Acupuncture's Multisystem Neuroimmunomodulation: Central-Peripheral Interactions in Gastroenteric, Psychiatric, and Chronic Pain Disorders.CNS neuroscience & therapeutics · 2025Review
- Effects of 650 nm laser acupuncture on cartilage, bone, and skeletal muscle in osteoarthritis.Bone reports · 2025Article
- The effect of stepwise acupuncture on cognition, insomnia, and tremors after traumatic brain injury: a case report.Journal of medical case reports · 2025Article
- Brain activities responding to acupuncture at acupoint in healthy subjects: a study protocol based on task-based fMRI.Frontiers in neurology · 2025Article
- Article
- Effects of anterior sciatic nerve acupuncture on lower limb paralysis after cerebral infarction: study protocol for a randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- A multimodal MRI study of XNKQ acupuncture for limb dysfunction after ischemic stroke: a randomized controlled study protocol.Frontiers in neurology · 2024Article
- The neural effects of acupuncture for stroke: a protocol for systematic review and meta-analysis based on fMRI.Frontiers in neuroscience · 2024Article
- Objectivization study of acupunctureFrontiers in neuroscience · 2024Review
- Immediate neural effects of acupuncture manipulation time for stroke with motor dysfunction: a fMRI pilot study.Frontiers in neuroscience · 2023Article
- Artificial intelligence-directed acupuncture: a review.Chinese medicine · 2022Review
- Sensorimotor Responses in Post-Stroke Hemiplegic Patients Modulated by Acupuncture at Yanglingquan (GB34): A fMRI Study Using Intersubject Functional Correlation (ISFC) Analysis.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural mechanisms of acupuncture are not well-understood. Over the past decades, an increasing number of studies have used MRI to investigate the response of the brain to acupuncture. The current review aims to provide an update on acupuncture therapy in disease. The PubMed, Embase, Web of Science, and Cochrane Library databases were searched from inception to January 31, 2021. Article selection and data extraction were conducted by two review authors. A total of 107 publications about MRI in acupuncture were included, the collective findings of which were as follows: (1) stroke and GB34 (Yanglingquan) are the most studied disease and acupoint. Related studies suggested that the mechanism of acupuncture treatment for stroke may associate with structural and functional plasticity, left and right hemispheres balance, and activation of brain areas related to movement and cognition. GB34 is mainly used in stroke and Parkinson's disease, which mainly activates brain response in the premotor cortex, the supplementary motor area, and the supramarginal gyrus; (2) resting-state functional MRI (rs-fMRI) and functional connectivity (FC) analysis are the most frequently used approaches; (3) estimates of efficacy and brain response to acupuncture depend on the type of sham acupuncture (SA) used for comparison. Brain processing after acupuncture differs between patients and health controls (HC) and occurs mainly in disorder-related areas. Factors that influence the effect of acupuncture include depth of needling, number and locations of acupoints, and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.