ArticleFrontiers in neuroscience2021
Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent Stimulation.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effects of visually induced motor imagery-based brain-computer interface training on motor function in patients with incomplete spinal cord injury: a small-sample exploratory trial.Frontiers in neurologyTrial
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances.Microsystems & nanoengineering · 2025Review
- Iris 128x: open-source 128 channel headstages for neural stimulation and recording.Journal of neural engineering · 2025Article
- Manipulation of neuronal activity by an artificial spiking neural network implemented on a closed-loop brain-computer interface in non-human primates.Journal of neural engineering · 2025Article
- Article
- Vagus nerve stimulation modulates distinct acetylcholine receptors on B cells and limits the germinal center response.Science advances · 2024Article
- Electroencephalogram-based adaptive closed-loop brain-computer interface in neurorehabilitation: a review.Frontiers in computational neuroscience · 2024Review
- Considerations and discussions on the clear definition and definite scope of brain-computer interfaces.Frontiers in neuroscience · 2024Review
- Use of Invasive Brain-Computer Interfaces in Pediatric Neurosurgery: Technical and Ethical Considerations.Journal of child neurology · 2023Review
- Local field potentials and single unit dynamics in motor cortex of unconstrained macaques during different behavioral states.Frontiers in neuroscience · 2023Article
- Neuromorphic computing facilitates deep brain-machine fusion for high-performance neuroprosthesis.Frontiers in neuroscience · 2023Article
- Recruitment and Differential Firing Patterns of Single Units During Conditioning to a Tone in a Mute Locked-In Human.Frontiers in human neuroscience · 2022Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Toward addressing many neuroprosthetic applications, the Neurochip3 (NC3) is a multichannel bidirectional brain-computer interface that operates autonomously and can support closed-loop activity-dependent stimulation. It consists of four circuit boards populated with off-the-shelf components and is sufficiently compact to be carried on the head of a non-human primate (NHP). NC3 has six main components: (1) an analog front-end with an Intan biophysical signal amplifier (16 differential or 32 single-ended channels) and a 3-axis accelerometer, (2) a digital control system comprised of a Cyclone V FPGA and Atmel SAM4 MCU, (3) a micro SD Card for 128 GB or more storage, (4) a 6-channel differential stimulator with ±60 V compliance, (5) a rechargeable battery pack supporting autonomous operation for up to 24 h and, (6) infrared transceiver and serial ports for communication. The NC3 and earlier versions have been successfully deployed in many closed-loop operations to induce synaptic plasticity and bridge lost biological connections, as well as deliver activity-dependent intracranial reinforcement. These paradigms to strengthen or replace impaired connections have many applications in neuroprosthetics and neurorehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.