ReviewFrontiers in neuroscience2021
Vagus Nerve Stimulation as a Potential Adjuvant to Rehabilitation for Post-stroke Motor Speech Disorders.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effects of Transcutaneous Auricular Vagus Nerve Stimulation With Rehabilitation on the Recovery of Upper Extremity Function After Stroke: A Systematic Review and Meta-Analysis.Neural plasticity · 2025Pooled it
- Two decades of vagus nerve stimulation for stroke: a bibliometric analysis.Frontiers in neurology · 2025Pooled it
- Risk factors of dysphagia in patients with ischemic stroke: A meta-analysis and systematic review.PloS one · 2022Pooled it
- Second or subsequent microvascular free flaps in head and neck reconstructive surgery: a narrative review.Annals of medicine and surgery (2012) · 2026Article
- Vagus Nerve Stimulation for Neuromodulation: Evolution from Bench to Bedside.Neurology international · 2026Article
- Percutaneous Electrical Nerve Field Stimulation Improves Weight and Other Anthropometric Outcomes in Children and Adolescents With Functional Dyspepsia Who Restrict Their Oral Intake.Neurogastroenterology and motility · 2026Article
- Emerging Therapeutic Strategies in Intracerebral Hemorrhage: Enhancing Neurogenesis and Functional Recovery.MedComm · 2025Review
- Vagus Nerve Stimulation in Stroke Management: Brief Review of Evolution and Present Applications Paired with Rehabilitation.Brain sciences · 2025Review
- Vagus nerve stimulation for stroke rehabilitation: Neural substrates, neuromodulatory effects and therapeutic implications.The Journal of physiology · 2025Review
- Percutaneous Electrical Nerve Field Stimulation in Children and Adolescents With Functional Dyspepsia-Integrating a Behavioral Intervention.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.Frontiers in integrative neuroscience · 2024Review
- Non-Invasive Vagal Nerve Stimulation Pre-Treatment Reduces Neurological Dysfunction After Closed Head Injury in Mice.Neurotrauma reports · 2024Article
- Research hotspots and frontiers of vagus nerve stimulation in stroke: a bibliometric analysis.Frontiers in neuroscience · 2024Review
- Transcutaneous vagus nerve stimulation at nonspecific timings during training can compromise motor adaptation in healthy humans.Journal of neurophysiology · 2023Article
- Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications.Frontiers in aging neuroscience · 2023Review
- Transcutaneous auricular vagus nerve stimulation on upper limb motor function with stroke: a functional near-infrared spectroscopy pilot study.Frontiers in neuroscience · 2023Article
- Narrative Review of Noninvasive Brain Stimulation in Stroke Rehabilitation.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Non-invasive Vagus Nerve Stimulation in Cerebral Stroke: Current Status and Future Perspectives.Frontiers in neuroscience · 2022Review
- Bibliometric analysis of publication trends and research hotspots in vagus nerve stimulation: A 20-year panorama.Frontiers in neurology · 2022Article
- How to fail with paired VNS therapy.Brain stimulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Stroke often leaves lasting impairments affecting orofacial function. While speech therapy is able to enhance function after stroke, many patients see only modest improvements after treatment. This partial restoration of function after rehabilitation suggests that there is a need for further intervention. Rehabilitative strategies that augment the effects of traditional speech therapy hold promise to yield greater efficacy and reduce disability associated with motor speech disorders. Recent studies demonstrate that brief bursts of vagus nerve stimulation (VNS) can facilitate the benefits of rehabilitative interventions. VNS paired with upper limb rehabilitation enhances recovery of upper limb function in patients with chronic stroke. Animal studies reveal that these improvements are driven by VNS-dependent synaptic plasticity in motor networks. Moreover, preclinical evidence demonstrates that a similar strategy of pairing VNS can promote synaptic reorganization in orofacial networks. Building on these findings, we postulate that VNS-directed orofacial plasticity could target post-stroke motor speech disorders. Here, we outline the rationale for pairing VNS with traditional speech therapy to enhance recovery in the context of stroke of speech motor function. We also explore similar treatments that aim to enhance synaptic plasticity during speech therapy, and how VNS differs from these existing therapeutic strategies. Based on this evidence, we posit that VNS-paired speech therapy shows promise as a means of enhancing recovery after post-stroke motor speech disorders. Continued development is necessary to comprehensively establish and optimize this approach, which has the potential to increase quality of life for the many individuals suffering with these common impairments.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.