ArticleNature medicine2021
Prognostic value of polygenic risk scores for adults with psychosis.
Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia.Biological psychiatry · 2023Pooled it
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Biomarkers for Predicting Clinical Deterioration in Schizophrenia-Spectrum Disorders: A Systematic Review.Brain sciences · 2026Review
- A transcriptional program associated with neurotransmission in the living human brain.Molecular psychiatry · 2026Article
- Upregulation of DNA repair-related genes in the prefrontal cortex of patients with schizophrenia with low genetic risk.Schizophrenia (Heidelberg, Germany) · 2026Article
- Genetics to Improve Outcomes in Schizophrenia (GENios): A within-case molecular genetic study protocol.PloS one · 2026Article
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.Nature communications · 2025Article
- Pharmacologic and genetic evidence converge on mechanisms of psychotic illness.Translational psychiatry · 2025Article
- Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- Family History in the Context of CKD.Journal of the American Society of Nephrology : JASN · 2025Article
- Clinical associations with treatment resistance in depression: An electronic health record study.Psychiatry research · 2024Article
- Optimising the use of electronic medical records for large scale research in psychiatry.Translational psychiatry · 2024Review
- Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits.Nature neuroscience · 2023Review
- Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis.Translational psychiatry · 2023Article
- The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research.Molecular psychiatry · 2023Review
- Deep Learning for Cross-Diagnostic Prediction of Mental Disorder Diagnosis and Prognosis Using Danish Nationwide Register and Genetic Data.JAMA psychiatry · 2023Article
- Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts.Cell genomics · 2023Article
- Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis.Molecular psychiatry · 2022Article
- Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 1 country.
Funding
Abstract
Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor outcomes in real-world clinical practice. To date, few studies have assessed the prognostic value of PRS relative to standards of care. Schizophrenia (SCZ), the archetypal psychotic illness, is an ideal test case for this because the predictive power of the SCZ PRS exceeds that of most other common diseases. Here, we analyzed clinical and genetic data from two multi-ethnic cohorts totaling 8,541 adults with SCZ and related psychotic disorders, to assess whether the SCZ PRS improves the prediction of poor outcomes relative to clinical features captured in a standard psychiatric interview. For all outcomes investigated, the SCZ PRS did not improve the performance of predictive models, an observation that was generally robust to divergent case ascertainment strategies and the ancestral background of the study participants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.