Evidence map›Paper›PMID 34489564›Full record

ArticleNature chemistry2021

Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures.

Tong Bian, Andrea Gardin, Julius Gemen, Lothar Houben, Claudio Perego, Byeongdu Lee, Nadav Elad, Zonglin Chu, Giovanni M Pavan, Rafal Klajn

Abstract read
In one paragraph

Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Toughening Artificial Spider Silk via Glue-Like Nanoparticle Crosslinks.Advanced materials (Deerfield Beach, Fla.) · 2026
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  14. [Formation mechanisms, construction, and performance evaluation of self-assembled nanoparticles derived from natural products].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  15. Article
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tong BianDepartment of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Andrea GardinDepartment of Innovative Technologies, University of Applied Sciences and Arts of Southern Switzerland, Lugano-Viganello, Switzerland.ORCID http://orcid.org/0000-0002-1587-3862
Julius GemenDepartment of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-9735-0167
Lothar HoubenDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
Claudio PeregoDepartment of Innovative Technologies, University of Applied Sciences and Arts of Southern Switzerland, Lugano-Viganello, Switzerland.ORCID http://orcid.org/0000-0001-8885-3080
Byeongdu LeeX-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Lemont, IL, USA.ORCID http://orcid.org/0000-0003-2514-8805
Nadav EladDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
Zonglin ChuDepartment of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Giovanni M PavanDepartment of Innovative Technologies, University of Applied Sciences and Arts of Southern Switzerland, Lugano-Viganello, Switzerland.ORCID http://orcid.org/0000-0002-3473-8471
Rafal KlajnDepartment of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel. rafal.klajn@weizmann.ac.il.ORCID http://orcid.org/0000-0002-6320-8875

Funding

European Research Council 820008
6 · The paper itself

Abstract

Coulombic interactions can be used to assemble charged nanoparticles into higher-order structures, but the process requires oppositely charged partners that are similarly sized. The ability to mediate the assembly of such charged nanoparticles using structurally simple small molecules would greatly facilitate the fabrication of nanostructured materials and harnessing their applications in catalysis, sensing and photonics. Here we show that small molecules with as few as three electric charges can effectively induce attractive interactions between oppositely charged nanoparticles in water. These interactions can guide the assembly of charged nanoparticles into colloidal crystals of a quality previously only thought to result from their co-crystallization with oppositely charged nanoparticles of a similar size. Transient nanoparticle assemblies can be generated using positively charged nanoparticles and multiply charged anions that are enzymatically hydrolysed into mono- and/or dianions. Our findings demonstrate an approach for the facile fabrication, manipulation and further investigation of static and dynamic nanostructured materials in aqueous environments.

Identifiers

PMID34489564
PMCPMC7611764

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.