ArticleScientific reports2021
Essential tremor amplitude modulation by median nerve stimulation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Essential Tremor Suppression with a Novel Anti-Tremor Orthosis: A Randomized Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial.Intensive care medicine · 2023Trial
- Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.Movement disorders clinical practice · 2025Review
- Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor.Brain : a journal of neurology · 2025Article
- An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility.IEEE journal of translational engineering in health and medicine · 2025Article
- Mapping of the central sulcus using non-invasive ultra-high-density brain recordings.Scientific reports · 2024Article
- Shaking Up Essential Tremor: Peripheral Devices and Mechanical Strategies to Reduce Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface.BMC ophthalmology · 2022Article
- Analyzing the Effects of Parameters for Tremor Modulation via Phase-Locked Electrical Stimulation on a Peripheral Nerve.Journal of personalized medicine · 2022Article
- Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.Frontiers in aging neuroscience · 2022Review
- Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor.Journal of neuroengineering and rehabilitation · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Essential tremor is a common neurological disorder, characterised by involuntary shaking of a limb. Patients are usually treated using medications which have limited effects on tremor and may cause side-effects. Surgical therapies are effective in reducing essential tremor, however, the invasive nature of these therapies together with the high cost, greatly limit the number of patients benefiting from them. Non-invasive therapies have gained increasing traction to meet this clinical need. Here, we test a non-invasive and closed-loop electrical stimulation paradigm which tracks peripheral tremor and targets thalamic afferents to modulate the central oscillators underlying tremor. To this end, 9 patients had electrical stimulation delivered to the median nerve locked to different phases of tremor. Peripheral stimulation induced a subtle but significant modulation in five out of nine patients-this modulation consisted mainly of amplification rather than suppression of tremor amplitude. Modulatory effects of stimulation were more pronounced when patient's tremor was spontaneously weaker at stimulation onset, when significant modulation became more frequent amongst subjects. This data suggests that for selected individuals, a more sophisticated control policy entailing an online estimate of both tremor phase and amplitude, should be considered in further explorations of the treatment potential of tremor phase-locked peripheral stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.