Evidence map›Paper›PMID 34489452›Full record

ArticleNature communications2021

MEG source imaging detects optogenetically-induced activity in cortical and subcortical networks.

Gregory E Alberto, Jennifer R Stapleton-Kotloski, David C Klorig, Emily R Rogers, Christos Constantinidis, James B Daunais, Dwayne W Godwin

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
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  4. Spatial Filters-In Search of the Virtual Electrode.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Multimodal MEG and Microstructure-MRI Investigations of the Human Hippocampal Scene Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Neocortical and Hippocampal Theta Oscillations Track Audiovisual Integration and Replay of Speech Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. A role for retro-splenial cortex in the task-related P3 network.bioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
  13. The hearing hippocampus.Progress in neurobiology · 2022
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gregory E Alberto *Wake Forest School of Medicine; Department of Neurobiology and Anatomy, Winston-Salem, NC, USA. gregory.e.alberto@hitchcock.org.ORCID http://orcid.org/0000-0002-2835-7592
Jennifer R Stapleton-Kotloski *Wake Forest School of Medicine Department of Neurology, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-5874-7500
David C KlorigWake Forest School of Medicine; Department of Neurobiology and Anatomy, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-8756-771X
Emily R RogersWake Forest School of Medicine; Department of Neurobiology and Anatomy, Winston-Salem, NC, USA.
Christos ConstantinidisWake Forest School of Medicine; Department of Neurobiology and Anatomy, Winston-Salem, NC, USA.
James B DaunaisWake Forest School of Medicine Department of Physiology and Pharmacology, Winston-Salem, NC, USA.
Dwayne W GodwinWake Forest School of Medicine; Department of Neurobiology and Anatomy, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-0376-4968
Wake Forest University · USW. G. (Bill) Hefner VA Medical Center · US

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Colleen A Hanlon · 2018 to 2026
$16.2M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
Mechanisms of Alcohol WithdrawalR01AA016852 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GODWIN, DWAYNE W · 2008 to 2024
$5.5M
Translational Studies on Early-life Stress and Vulnerability to Alcohol AddictionP01AA021099 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI JONES, SARA RAULERSON · 2012 to 2016
$2.8M
NEUROMODULATOR INFLUENCES ON PREFRONTAL CORTICAL FUNCTIONR01MH097695 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLAKE, DAVID T, CONSTANTINIDIS, CHRISTOS · 2013 to 2017
$1.9M
Molecular Mechanism of Hippocampal network excitability in a novel, in vivo model of Tuberous Sclerosis ComplexR01NS105005 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAAB-GRAHAM, KIMBERLY FRANCES · 2018 to 2022
$1.9M
Training Program in Multisensory ProcessesT32NS073553 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEIN, BARRY E · 2011 to 2020
$1.7M
Evaluating Gene Therapy Strategies to Treat Epilepsy Using a Novel Optogenetic Measure of Network Excitability and Seizure SusceptibilityR21NS116519 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GODWIN, DWAYNE W, KLORIG, DAVID C · 2020 to 2021
$434k
Advancing Neuroimaging in Nonhuman PrimatesR21AA028007 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAUNAIS, JAMES B · 2020 to 2021
$396k
An optogenetic investigation of CNS sensitization following alcohol withdrawalF30AA023708 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALBERTO, GREGORY ERICK · 2014 to 2019
$228k
NCATS NIH HHS UL1 TR001420NIAAA NIH HHS F30 AA023708NIAAA NIH HHS P01 AA021099NIAAA NIH HHS P50 AA026117NIAAA NIH HHS R01 AA016852NIAAA NIH HHS R21 AA028007NIH HHS P40 OD010965NIMH NIH HHS R01 MH097695NINDS NIH HHS R01 NS105005NINDS NIH HHS R21 NS116519NINDS NIH HHS T32 NS073553
6 · The paper itself

Abstract

Magnetoencephalography measures neuromagnetic activity with high temporal, and theoretically, high spatial resolution. We developed an experimental platform combining MEG-compatible optogenetic techniques in nonhuman primates for use as a functional brain-mapping platform. Here we show localization of optogenetically evoked signals to known sources in the superficial arcuate sulcus of cortex and in CA3 of hippocampus at a resolution of 750 µm

Indexed as

AnimalsBacterial ProteinsBrainChlorocebus aethiopsEvoked PotentialsFemaleFunctional NeuroimagingLuminescent ProteinsMagnetoencephalographyMicroscopy, ConfocalModels, NeurologicalNerve NetOptogeneticsSignal Processing, Computer-AssistedBacterial ProteinsLuminescent Proteinsyellow fluorescent protein, Bacteria

Identifiers

PMID34489452
PMCPMC8421372
OpenAlexW3197649013

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.