ArticleNature communications2021
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
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182citing papers in PubMed
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Who cites it
182 citing papers in PubMed, 296 citations in OpenAlex.
- The Impact of Antigen Presentation on BBB Disruption and Neuroinflammation.Physiology (Bethesda, Md.) · 2026Review
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- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- Neurovascular Signaling in the Perivascular Space: Biophysical Principles and Disruption in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Biomedical Materials and Fabrication Methods for Construction of In Vitro Neurovascular Unit Models.Materials (Basel, Switzerland) · 2026Review
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- Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.Cell metabolism · 2026Article
- Microglia promote vascular remodeling in a mouse model of chronic stress.Brain, behavior, and immunity · 2026Article
- Friend or foe? Glial-vascular interactions in health and neurodegenerative disease.Pharmacological reviews · 2026Review
- Glioma-Associated Microglia Augment Neuronal Hyper-Excitability in Glioma.Brain tumor research and treatment · 2026Review
- The roles of microglia and astrocytes in inflammasomes and neurological disorders.Neural regeneration research · 2026Article
- Ythdf2 loss in microglia aggravates ischemic retinopathy by increasing microglia activation and microvascular anomalies.Journal of advanced research · 2026Article
- Hidden battles: dissecting host-fungal interactions and immune heterogeneity in infection outcomes.mSphere · 2026Review
- Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish.Nature immunology · 2026Article
- Vessel-associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2026Article
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson's Disease.Cellular and molecular neurobiology · 2026Review
- Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury.Cell death & disease · 2026Article
122 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 2 institutions in 2 countries.
Kanchan Bisht *Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Kenneth A Okojie *Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Kaushik Sharma *Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-2316-4609
Dennis H LentferinkDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-8747-1336
Yu-Yo SunDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Hong-Ru ChenDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-9016-2190
Joseph O UweruDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-0767-8212
Saipranusha AmancherlaDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Zainab CalcuttawalaDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Antony Brayan Campos-SalazarDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bruce CorlissRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-2962-7344
Lara JabbourDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jordan BenderothDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bria FriestadDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
William A MillsDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-7692-6294
Marie-Ève TremblayAxe Neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.ORCID http://orcid.org/0000-0003-2863-9626
Chia-Yi KuanDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ukpong B EyoDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA. ube9q@virginia.edu.ORCID http://orcid.org/0000-0002-1294-475X
University of Virginia · USUniversity of Victoria · CA
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0MBASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MPurinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7MHyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9MCreatine Transporter Deficiency and Brain EnergeticsR01NS108763 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2018 to 2022
$2.3MMicroglial-Neurovascular Dynamics and Regulation of Neurovascular Structure and FunctionR01NS122782 · NINDS · UNIVERSITY OF VIRGINIA · PI EYO, UKPONG BASSEY · 2021 to 2025
$2.0MCrosstalk of Innate and Adaptive Immunity in Infection-Sensitized Neonatal HIER01NS095064 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2016 to 2020
$1.7MMechanisms of capillary-associated microglial interactionsR21NS119727 · NINDS · UNIVERSITY OF VIRGINIA · PI EYO, UKPONG BASSEY · 2020 to 2021
$444kNHLBI NIH HHS P01 HL120840NHLBI NIH HHS R01 HL132177NHLBI NIH HHS R01 HL137112NHLBI NIH HHS T32 HL007284NINDS NIH HHS R01 NS095064NINDS NIH HHS R01 NS108763NINDS NIH HHS R01 NS122782NINDS NIH HHS R21 NS119727
Abstract
Microglia are brain-resident immune cells with a repertoire of functions in the brain. However, the extent of their interactions with the vasculature and potential regulation of vascular physiology has been insufficiently explored. Here, we document interactions between ramified CX3CR1
Indexed as
AnimalsBrainCell CountCerebrovascular CirculationConnexinsCX3C Chemokine Receptor 1Electrodes, ImplantedFemaleGene Expression RegulationGenes, ReporterGreen Fluorescent ProteinsMaleMiceMice, KnockoutMicrogliaMyeloid CellsConnexinsCX3C Chemokine Receptor 1Cx3cr1 protein, mouseGreen Fluorescent ProteinsNerve Tissue ProteinsP2ry12 protein, mousePanx1 protein, mouseReceptors, Purinergic P2Y12
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