Evidence map›Paper›PMID 34489306›Full record

ArticleGut2021

Diet quality and risk and severity of COVID-19: a prospective cohort study.

Jordi Merino, Amit D Joshi, Long H Nguyen, Emily R Leeming, Mohsen Mazidi, David A Drew, Rachel Gibson, Mark S Graham, Chun-Han Lo, Joan Capdevila and 20 more

Open access · bronzeAbstract read
In one paragraph

Article in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 2 pooled it
35.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 2 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. Pooled it
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  5. Do Diet, Oral Hygiene, and Sleep Habits Correlate with Severe COVID-19?International journal of preventive medicine · 2026
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 6 institutions in 3 countries.

Jordi MerinoDiabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8312-1438
Amit D JoshiClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7581-6934
Long H NguyenClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5436-4219
Emily R LeemingDepartment of Twin Research, King's College London, London, UK.ORCID 0000-0002-0531-4901
Mohsen MazidiDepartment of Twin Research, King's College London, London, UK.
David A DrewClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-8813-0816
Rachel GibsonDepartment of Nutritional Sciences, King's College London, London, UK.
Mark S GrahamSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Chun-Han LoClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8202-4513
Joan CapdevilaZoe Limited, London, UK.
Benjamin MurraySchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Christina HuZoe Limited, London, UK.
Somesh SelvachandranZoe Limited, London, UK.
Alexander HammersSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Shilpa N BhupathirajuDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Shreela V SharmaDepartment of Epidemiology, Human Genetics, and Environmental Sciences, UT Health School of Public Health, Houston, Texas, USA.
Carole SudreSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Christina M AstleyProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sohee KwonClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.
Wenjie MaClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA.
Cristina MenniDepartment of Twin Research, King's College London, London, UK.ORCID 0000-0001-9790-0571
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sebastien OurselinSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
Claire J StevesDepartment of Twin Research, King's College London, London, UK.
Jonathan WolfZoe Limited, London, UK.
Paul W FranksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Timothy D SpectorDepartment of Nutritional Sciences, King's College London, London, UK.
Sarah BerryDepartment of Nutritional Sciences, King's College London, London, UK.
Andrew T ChanClinical and Translational Epidemiological Unit, Massachusetts General Hospital, Boston, MA, USA achan@mgh.harvard.edu.
King's College London · GBHarvard University · USZOE (United Kingdom) · GBBrigham and Women's Hospital · USBroad Institute · USUniversity of Texas Health Science Center at Dallas · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN K. GRINSPOON · 1994 to 2026
$31.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adultsR24ES028521 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, LADEN, FRANCINE · 2018 to 2022
$2.1M
Dietary strategies for rational manipulation of the gut microbiome in inflammatory bowel diseaseK23DK125838 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NGUYEN, LONG H · 2020 to 2024
$1.0M
Risk Prediction of Symptomatic Gallbladder DiseaseK01DK110267 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSHI, AMIT DOLAR · 2016 to 2021
$876k
Impact of Aspirin on the Gut Microbiome and Mucosal MicroenvironmentK01DK120742 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DREW, DAVID A · 2020 to 2024
$793k
Seasonal and Viral Determinants of Type 1 Diabetes Onset, Remission, and Glycemic ControlK23DK120899 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ASTLEY, CHRISTINA M. · 2019 to 2021
$682k
EPA EP-W-17-011NCI NIH HHS R01 CA138962NCI NIH HHS R35 CA253185NHLBI NIH HHS U01 HL145386NIDDK NIH HHS K01 DK110267NIDDK NIH HHS K01 DK120742NIDDK NIH HHS K23 DK120899NIDDK NIH HHS K23 DK125838NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK046200NIEHS NIH HHS R24 ES028521Wellcome Trust
6 · The paper itself

Abstract

objectivePoor metabolic health and unhealthy lifestyle factors have been associated with risk and severity of COVID-19, but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its interaction with socioeconomic deprivation.

designWe used data from 592 571 participants of the smartphone-based COVID-19 Symptom Study. Diet information was collected for the prepandemic period using a short food frequency questionnaire, and diet quality was assessed using a healthful Plant-Based Diet Score, which emphasises healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate HRs and 95% CIs for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalisation with oxygen support, respectively.

resultsOver 3 886 274 person-months of follow-up, 31 815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR 0.91; 95% CI 0.88 to 0.94) and severe COVID-19 (HR 0.59; 95% CI 0.47 to 0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (P

conclusionsA diet characterised by healthy plant-based foods was associated with lower risk and severity of COVID-19. This association may be particularly evident among individuals living in areas with higher socioeconomic deprivation.

Indexed as

AdolescentAdultAgedCOVID-19DietDiet, HealthyDiet SurveysFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSeverity of Illness IndexSocioeconomic FactorsSurveys and QuestionnairesCOVID-19dietdietary factorsinfectious disease

Identifiers

PMID34489306
PMCPMC8500931
OpenAlexW3196917283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.