Evidence map›Paper›PMID 34488885›Full record

ReviewStem cell research & therapy2021

Translational models of 3-D organoids and cancer stem cells in gastric cancer research.

Kenly Wuputra, Chia-Chen Ku, Kohsuke Kato, Deng-Chyang Wu, Shigeo Saito, Kazunari K Yokoyama

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Kenly WuputraGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Chia-Chen KuGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Kohsuke KatoDepartment of Infection Biology, Graduate School of Comprehensive Human Sciences, The University of Tsukuba, Tsukuba, 305-8577, Japan.
Deng-Chyang WuRegenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Shigeo SaitoWaseda Research Institute of Science and Engineering, Waseda University, Tokyo, 169-0051, Japan. saict1@maple.ocn.ne.jp.
Kazunari K YokoyamaGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. kazu@kmu.edu.tw.ORCID 0000-0001-8508-7587
Kaohsiung Medical University · TWWaseda University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is postulated as a general concept of cancer stem cells (CSCs) that they can produce cancer cells overtly and repopulate cancer progenitor cells indefinitely. The CSC niche is part of a specialized cancer microenvironment that is important to keep the phenotypes of CSCs. Stem cell- and induced pluripotent stem cell (iPSC)-derived organoids with genetic manipulation are beneficial to the investigation of the regulation of the microenvironment of CSCs. It would be useful to assess the efficiency of the cancer microenvironment on initiation and progression of cancers. To identify CSCs in cancer tissues, normal cell organoids and gastric cancer organoids from the cancerous areas, as well as iPSCs, were established several years ago. However, many questions remain about the extent to which these cultures recapitulate the development of the gastrointestinal tract and the mechanism of Helicobacter pylori-induced cancer progression. To clarify the fidelity of human organoid models, we have noted several key issues for the cultivation of, and differences between, normal and cancerous organoids. We developed precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications. In addition, the current knowledge on gastrointestinal CSC research, including the topic of CSC markers, cancer cell reprogramming, and application to target cancer cell plasticity through niches, should be reinforced. We discuss the progression of cancers derived from human gastric organoids and the identification of CSCs.

Indexed as

Induced Pluripotent Stem CellsStomach NeoplasmsHumansNeoplastic Stem CellsOrganoidsTumor MicroenvironmentCancer microenvironmentCancer stem cellsGastric cancerHuman gastric organoidsPatient-specific organoid libraryTranslational researchTumor suppressor genes

Identifiers

PMID34488885
PMCPMC8420044
OpenAlexW3197683579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.