ArticleGenome biology2021
Genomic basis underlying the metabolome-mediated drought adaptation of maize.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Metabolite-Based Genome-Wide Association Studies of Large-Scale Metabolome Analysis to Illustrate Alterations in the Metabolite Landscape of Plants upon Responses to Stresses.Methods in molecular biology (Clifton, N.J.) · 2023Guideline
- Integration of the D-Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance.The New phytologist · 2026Review
- Genetic coupling of leaf and kernel-related traits shapes drought adaptation in maize.The Plant journal : for cell and molecular biology · 2026Article
- Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.Nature genetics · 2026Article
- Multi-Omics Dissection of Drought Stress Responses in Crops: From Molecular Regulatory Networks to Climate-Resilient Breeding Applications.International journal of molecular sciences · 2026Review
- Different Distribution of Carotenoid Content in Periderm-Phloem-Xylem of Red Carrot Taproots.Molecular biotechnology · 2026Article
- Population Genomic Structure of Sorghum Landraces Across Landscape, Environment and Culture.Molecular ecology · 2026Article
- Mulberry Drought Diagnosis: Integrating Proximal Sensing and Metabolomics for Remote Monitoring.Plants (Basel, Switzerland) · 2026Article
- CQD: A Rapid and Accurate Tool for Identifying High-Confidence QTLs and Candidate Genes from GWAS Summary Statistics.International journal of molecular sciences · 2026Article
- Physiological, metabolic, and transcriptional responses of contrasting sorghum (Sorghum bicolor (L.) Moench) cultivars to drought.Plant cell reports · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Progress and Impacts of "Omics" Technologies in Understanding the Drought Response in Cassava: Adoption for Food Security in Africa.Plant-environment interactions (Hoboken, N.J.) · 2025Review
- Adjustments of plant primary metabolism in the face of climate change.Journal of experimental botany · 2025Review
- Population genomic structure of sorghum landraces across landscape, environment and culture.bioRxiv : the preprint server for biology · 2025Article
- A pangenome of maize provides genetic insights into drought resistance.Nature genetics · 2025Article
- High-resolution time-series transcriptomic and metabolomic profiling reveals the regulatory mechanism underlying salt tolerance in maize.Genome biology · 2025Article
- Advances in Functional Genomics for Exploring Abiotic Stress Tolerance Mechanisms in Cereals.Plants (Basel, Switzerland) · 2025Review
- Unlocking Plant Resilience: Metabolomic Insights into Abiotic Stress Tolerance in Crops.Metabolites · 2025Review
- A panoramic view of cotton resistance toiMeta · 2025Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrought is a major environmental disaster that causes crop yield loss worldwide. Metabolites are involved in various environmental stress responses of plants. However, the genetic control of metabolomes underlying crop environmental stress adaptation remains elusive.
resultsHere, we perform non-targeted metabolic profiling of leaves for 385 maize natural inbred lines grown under well-watered as well as drought-stressed conditions. A total of 3890 metabolites are identified and 1035 of these are differentially produced between well-watered and drought-stressed conditions, representing effective indicators of maize drought response and tolerance. Genetic dissections reveal the associations between these metabolites and thousands of single-nucleotide polymorphisms (SNPs), which represented 3415 metabolite quantitative trait loci (mQTLs) and 2589 candidate genes. 78.6% of mQTLs (2684/3415) are novel drought-responsive QTLs. The regulatory variants that control the expression of the candidate genes are revealed by expression QTL (eQTL) analysis of the transcriptomes of leaves from 197 maize natural inbred lines. Integrated metabolic and transcriptomic assays identify dozens of environment-specific hub genes and their gene-metabolite regulatory networks. Comprehensive genetic and molecular studies reveal the roles and mechanisms of two hub genes, Bx12 and ZmGLK44, in regulating maize metabolite biosynthesis and drought tolerance.
conclusionOur studies reveal the first population-level metabolomes in crop drought response and uncover the natural variations and genetic control of these metabolomes underlying crop drought adaptation, demonstrating that multi-omics is a powerful strategy to dissect the genetic mechanisms of crop complex traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.