Evidence map›Paper›PMID 34488824›Full record

Trial reportTrials2021

Acupuncture for combat post-traumatic stress disorder: trial development and methodological approach for a randomized controlled clinical trial.

Michael Hollifield, An-Fu Hsiao, Kala Carrick, Andrea Gory Munoz, Teresa Calloway, Karen Cocozza, Besa Smith, Tyler Smith, Tanja Jovanovic, Seth Norrholm and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02869646 (Acupuncture for PTSD in Combat Veterans), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02869646 nacompletednot on this map

Acupuncture for PTSD in Combat Veterans

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2018 to 2022Enrolled92ConditionsPosttraumatic Stress DisorderArmsProcedure: Acupuncture, Procedure: Sham acupuncture
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Michael HollifieldTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA. michael.hollifield@va.gov.ORCID http://orcid.org/0000-0002-6576-8673
An-Fu HsiaoTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Kala CarrickTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Andrea Gory MunozTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Teresa CallowayTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Karen CocozzaTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Besa SmithUC Irvine Health Policy Research Institute, 100 Theory, Suite 110, Irvine, CA, 92697, USA.
Tyler SmithUC Irvine Health Policy Research Institute, 100 Theory, Suite 110, Irvine, CA, 92697, USA.
Tanja JovanovicAnalydata, 3835 Centraloma Drive, San Diego, CA, 92107, USA.
Seth NorrholmAnalydata, 3835 Centraloma Drive, San Diego, CA, 92107, USA.
Estate SokhadzeDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Drive, Detroit, MI, 48201, USA.
Christopher ReistTibor Rubin VA Medical Center, 5109 E. 7th Street, Long Beach, CA, 90822, USA.
Tibor Rubin VA Medical Center · USUC Irvine Health · USGeorge Washington University · USPrisma Health · USUniversity of California, Riverside · USWayne State University · US

Funding

Acupuncture for PTSD in Combat VeteransI01CX001416 · VA · VETERANS HEALTH ADMINISTRATION · PI HOLLIFIELD, MICHAEL · 2017 to 2023
–
Clinical Sciences Research and Development - VA Office of Research and Development CX-15-006CSRD VA I01 CX001416
6 · The paper itself

Abstract

backgroundPost-traumatic stress disorder (PTSD) is a significant public health problem, affecting approximately 7% of the general population and 13-18% of the combat Veteran population. The first study using acupuncture for PTSD in a civilian population showed large pre- to post-treatment effects for an empirically developed verum protocol, which was equivalent to group cognitive behavior therapy and superior to a wait-list control. The primary objective of this study is to determine both clinical and biological effects of verum acupuncture for combat-related PTSD in treatment-seeking US Veterans.

methodsThis is a two-arm, parallel-group, prospective randomized placebo-controlled clinical trial. The experimental condition is verum acupuncture and the placebo control is sham (minimal) acupuncture in 1-h sessions, twice a week for 12 weeks. Ninety subjects will provide adequate power and will be allocated to group by an adaptive randomization procedure. The primary outcome is change in PTSD symptom severity from pre- to post-treatment. The secondary biological outcome is change from pre- to post-treatment in psychophysiological response, startle by electromyographic (EMG) eyeblink. Assessments will be conducted at pre-, mid-, post-, and 1-month post-treatment, blind to group allocation. Intent-to-treat analyses will be conducted. DISCUSSION: The study results will be definitive because both clinical and biological outcomes will be assessed and correlated. Issues such as the number needed for recruitment and improvement, use of sham acupuncture, choice of biological measure, and future research need will be discussed.

trial registrationClinicalTrials.gov NCT02869646 . Registered on 17 August 2016.

Indexed as

Acupuncture TherapyStress Disorders, Post-TraumaticVeteransHumansProspective StudiesTreatment OutcomeAcupunctureCombatPost-traumatic stressPsychophysiologyVeterans

Identifiers

PMID34488824
PMCPMC8419889
OpenAlexW3155710204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.