Evidence map›Paper›PMID 34488803›Full record

ArticleJournal of nanobiotechnology2021

NIR-II-driven and glutathione depletion-enhanced hypoxia-irrelevant free radical nanogenerator for combined cancer therapy.

Li Zhang, Yadi Fan, Zhe Yang, Mo Yang, Chun-Yuen Wong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Li Zhang *Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
Yadi Fan *Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR.
Zhe YangDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
Mo YangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR. mo.yang@polyu.edu.hk.
Chun-Yuen WongDepartment of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR. acywong@cityu.edu.hk.ORCID http://orcid.org/0000-0003-4780-480X
City University of Hong Kong · HKHong Kong Polytechnic University · HK

Funding

City University of Hong Kong 7005096City University of Hong Kong 7005257National Natural Science Foundation of China NSFC 31771077Research Grants Council, University Grants Committee CityU 11207117Research Grants Council, University Grants Committee CityU 11305920Research Grants Council, University Grants Committee PolyU 15216917Research Grants Council, University Grants Committee T42-103/16-N
6 · The paper itself

Abstract

backgroundThough the combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) appears to be very attractive in cancer treatment, hypoxia and overproduced glutathione (GSH) in the tumor microenvironment (TME) limit their efficacy for further application.

resultsIn this work, a smart hypoxia-irrelevant free radical nanogenerator (AIPH/PDA@CuS/ZIF-8, denoted as APCZ) was synthesized in situ via coating copper sulphide (CuS)-embedded zeolitic imidazolate framework-8 (ZIF-8) on the free radical initiator 2,2'-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH)-loaded polydopamine (PDA). APCZ showed promising GSH-depleting ability and near-infrared (NIR)-II photothermal performance for combined cancer therapy. Once internalized by 4T1 cells, the outer ZIF-8 was rapidly degraded to trigger the release of CuS nanoparticles (NPs), which could react with local GSH and sequentially hydrogen peroxide (H

conclusionsThe novel APCZ could realize the cooperative amplification effect of free radicals-based therapies by NIR-II light excitation and GSH consumption, and act as a contrast agent to improve PA imaging, holding tremendous potential for efficient diagnosis and treatment of deep-seated and hypoxic tumors.

Indexed as

AnimalsCell Line, TumorCombined Modality TherapyCopperFemaleFree RadicalsGlutathioneHumansHydrogen PeroxideHypoxiaLasersMiceMice, Inbred BALB CMice, NudeNanoparticlesNeoplasmsCopperFree RadicalsGlutathioneHydrogen PeroxideSulfidesAlkyl radicalGlutathione-depletingHydroxyl radicalHypoxia-irrelevantNIR-II photothermal therapy

Identifiers

PMID34488803
PMCPMC8420023
OpenAlexW3196900207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.