ArticleFrontiers in zoology2021
Mitonuclear mismatch alters nuclear gene expression in naturally introgressed Rhinolophus bats.
Article in Frontiers in zoology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Repeated Mitochondrial Capture With Limited Genomic Introgression in a Lizard Group.Molecular ecology · 2025Article
- Selection Increases Mitonuclear DNA Discordance but Reconciles Incompatibility in African Cattle.Molecular biology and evolution · 2025Article
- Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus.PloS one · 2025Article
- Chromosome-level genome and population genomics of the intermediate horseshoe bat (Zoological research · 2024Article
- Mapping mitonuclear epistasis using a novel recombinant yeast population.PLoS genetics · 2023Article
- Extensive alternative splicing triggered by mitonuclear mismatch in naturally introgressed Rhinolophus bats.Ecology and evolution · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMitochondrial function involves the interplay between mitochondrial and nuclear genomes. Such mitonuclear interactions can be disrupted by the introgression of mitochondrial DNA between taxa or divergent populations. Previous studies of several model systems (e.g. Drosophila) indicate that the disruption of mitonuclear interactions, termed mitonuclear mismatch, can alter nuclear gene expression, yet few studies have focused on natural populations.
resultsHere we study a naturally introgressed population in the secondary contact zone of two subspecies of the intermediate horseshoe bat (Rhinolophus affinis), in which individuals possess either mitonuclear matched or mismatched genotypes. We generated transcriptome data for six tissue types from five mitonuclear matched and five mismatched individuals. Our results revealed strong tissue-specific effects of mitonuclear mismatch on nuclear gene expression with the largest effect seen in pectoral muscle. Moreover, consistent with the hypothesis that genes associated with the response to oxidative stress may be upregulated in mitonuclear mismatched individuals, we identified several such gene candidates, including DNASE1L3, GPx3 and HSPB6 in muscle, and ISG15 and IFI6 in heart.
conclusionOur study reveals how mitonuclear mismatch arising from introgression in natural populations is likely to have fitness consequences. Underlying the processes that maintain mitonuclear discordance is a step forward to understand the role of mitonuclear interactions in population divergence and speciation.
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