ReviewMicrobial cell factories2021
Metabolic engineering for high yield synthesis of astaxanthin in Xanthophyllomyces dendrorhous.
Review in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Metabolic engineering of Dunaliella salina enhances astaxanthin production: combined effects of heterologous enzyme co-expression and dual-stress optimization.World journal of microbiology & biotechnology · 2026Article
- Enhancing Astaxanthin Production inMarine drugs · 2026Article
- Rhodotorula and Phaffia: pigment producing basidiomycetous yeasts for application in aquaculture practices.Archives of microbiology · 2025Review
- Advances in Metabolic Engineering for the Accumulation of Astaxanthin Biosynthesis.Molecular biotechnology · 2025Review
- Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites.3 Biotech · 2025Review
- EngineeredLife (Basel, Switzerland) · 2025Article
- Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering.Biological research · 2024Article
- Metabolic engineering of Mucor circinelloides to improve astaxanthin production.World journal of microbiology & biotechnology · 2024Article
- Identification of Potential New Genes Related to the SREBP Pathway inBiomolecules · 2024Article
- Combined 6-benzylaminopurine and HApplied microbiology and biotechnology · 2024Article
- Microbial astaxanthin: from bioprocessing to the market recognition.Applied microbiology and biotechnology · 2023Review
- Industrially Important Fungal Carotenoids: Advancements in Biotechnological Production and Extraction.Journal of fungi (Basel, Switzerland) · 2023Review
- Metabolic mechanism of astaxanthin biosynthesis in Xanthophyllomyces dendrorhous in response to sodium citrate treatment.Bioresources and bioprocessing · 2023Article
- Transcriptomics analysis and fed-batch regulation of high astaxanthin-producing Phaffia rhodozyma/Xanthophyllomyces dendrorhous obtained through adaptive laboratory evolution.Journal of industrial microbiology & biotechnology · 2023Article
- The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions.Molecules (Basel, Switzerland) · 2022Review
- GATA transcription factor WC2 regulates the biosynthesis of astaxanthin in yeast Xanthophyllomyces dendrorhous.Microbial biotechnology · 2022Article
- A Fast-Growing Oleaginous Strain ofLife (Basel, Switzerland) · 2022Article
- Effectively Improve the Astaxanthin Production by Combined Additives Regulating Different Metabolic Nodes inFrontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Astaxanthin is a carotenoid with a number of assets useful for the food, cosmetic and pharmaceutical industries. Nowadays, it is mainly produced by chemical synthesis. However, the process leads to an enantiomeric mixture where the biologically assimilable forms (3R, 3'R or 3S, 3'S) are a minority. Microbial production of (3R, 3'R) astaxanthin by Xanthophyllomyces dendrorhous is an appealing alternative due to its fast growth rate and easy large-scale production. In order to increase X. dendrorhous astaxanthin yields, random mutant strains able to produce from 6 to 10 mg/g dry mass have been generated; nevertheless, they often are unstable. On the other hand, site-directed mutant strains have also been obtained, but they increase only the yield of non-astaxanthin carotenoids. In this review, we insightfully analyze the metabolic carbon flow converging in astaxanthin biosynthesis and, by integrating the biological features of X. dendrorhous with available metabolic, genomic, transcriptomic, and proteomic data, as well as the knowledge gained with random and site-directed mutants that lead to increased carotenoids yield, we propose new metabolic engineering targets to increase astaxanthin biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.