Evidence map›Paper›PMID 34488728›Full record

ArticleBMC endocrine disorders2021

Comparisons of different exercise interventions on glycemic control and insulin resistance in prediabetes: a network meta-analysis.

Li Huang, Yingjie Fang, Lijun Tang

Open access · goldAbstract readNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  8. Effects of WatchingCardiovascular & hematological disorders drug targets · 2025
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  19. Evidence-Based Synthesis for Practice: Lifestyle Interventions in Type 2 Diabetes with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Li HuangInstitute of Physical Education, Soochow University, Suzhou, 215100, Jiangsu, China.
Yingjie FangShanghai Kangjian Foreign Language Experimental Middle School, Xuhui District, Shanghai, 200233, China.
Lijun TangInstitute of Physical Education, Shanghai Normal University, No. 5, Lane 14, Guilin West Street, Xuhui District, Shanghai, 200234, China. ljtang1976@shnu.edu.cn.
Nanjing Foreign Language School · CNShanghai Normal University · CNSoochow University · CN

Funding

the Fundamental Research Funds for the Central Universities Not applicable
6 · The paper itself

Abstract

backgroundIn order to recommend the optimal type of exercise for type 2 diabetes prevention, different exercise interventions were compared with respect to their effects on glycemic control and insulin resistance.

methodsStudies on the curative effect of aerobic exercise training (AET), resistance training (RT), or control training (CT) on prediabetes were retrieved from the PubMed, Embase, SPORTDiscus, and Cochrane Library databases. Body mass index (BMI); homeostasis model assessment of insulin resistance index (HOMA-IR); and fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and insulin levels were used as outcome indicators. The Q statistic was calculated to evaluate heterogeneity within studies. A fixed- or random-effects model was used for pooling data based on nonsignificant or significant heterogeneities. A consistency test was conducted using a node-splitting analysis.

resultsA total of 13 eligible studies were included. The results of the direct meta-analysis indicated that AET or RT could significantly reduce the HbA1c level in prediabetic individuals compared to CT [AET vs. CT: standardized mean difference (SMD) = - 0.6739, 95% confidence interval (CI) = - 0.9424 to - 0.4055 to RT vs. CT: SMD = - 1.0014, 95% CI = - 1.3582 to - 0.6446]. The findings from the network meta-analysis showed that there were no statistical differences among the four comparisons for all the indicators except for lower HbA1c level (SMD = - 0.75, 95% CI = - 1.31 to - 0.19) and HOMA-IR (SMD = - 1.03, 95% CI = - 1.96 to - 0.10) in the AET group than in the CT group. In addition, prediabetic individuals in the AET + RT group showed greater control of BMI and insulin and FBG levels than those in the other groups, whereas AET was the most effective in controlling HbA1c and HOMA-IR levels in prediabetic individuals.

conclusionAET, AET + RT, and RT exerted beneficial effects on insulin resistance and glycemic control in prediabetic patients. From the existing data, AET or AET + RT is preferentially recommended for these patients, although further studies may unveil RT as a promising therapy. Benefits from all types of exercise seem to occur in an intensity-dependent manner.

Indexed as

ExerciseInsulin ResistanceBiomarkersBlood GlucoseBody Mass IndexGlycated HemoglobinGlycemic ControlHumansPrediabetic StatePrognosisRandomized Controlled Trials as TopicBiomarkersBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanAerobic exercise trainingGlycemic controlInsulin resistanceNetwork meta-analysisPrediabetesResistance training

Identifiers

PMID34488728
PMCPMC8422751
OpenAlexW3196829805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.