Evidence map›Paper›PMID 34488670›Full record

ArticleBMC infectious diseases2021

Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases.

Xiaoyan Gai, Hongbin Chi, Wenli Cao, Lin Zeng, Lixue Chen, Weixia Zhang, Donghong Song, Ying Wang, Ping Liu, Rong Li and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  18. What is your diagnosis?Journal of the Turkish German Gynecological Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Xiaoyan Gai *Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, 49 N Garden Rd, Haidian District, Beijing, 100191, China.
Hongbin Chi *Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China.
Wenli Cao *Tuberculosis Department, Beijing Geriatric Hospital, 102699, Beijing, China.
Lin ZengClinical Epidemiology Research Center, Peking University Third Hospital, 100191, Beijing, China.
Lixue ChenCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China.
Weixia ZhangDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, 49 N Garden Rd, Haidian District, Beijing, 100191, China.
Donghong SongCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China.
Ying WangCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China.
Ping LiuCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China.
Rong LiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, 100191, Beijing, China. roseli001@sina.com.
Yongchang SunDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, 49 N Garden Rd, Haidian District, Beijing, 100191, China. suny@bjmu.edu.cn.
Peking University Third Hospital · CNPeking University · CNBeijing Geriatric Hospital · CNBeijing Obstetrics and Gynecology Hospital · CNNational Clinical Research Center for Digestive Diseases · CN

Funding

National Natural Science Foundation 81400041National Natural Science Foundation 81871212National Natural Science Foundation of China Youth Fund Project 81400038
6 · The paper itself

Abstract

backgroundWhile miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outcomes of patients after IVF-ET.

methodsData of infertile patients who received IVF-ET at Peking University Third Hospital between January 2012 and December 2017 were retrospectively analyzed. Patients who developed miliary TB during pregnancy were identified, and clinical characteristics of miliary TB were described.

resultsOut of 62,755 infertile women enrolled, 7137 (11.4 %) showed signs of prior pulmonary TB on chest X-ray (CXR). Among the 15,136 women (mean age: 33.2 ± 5.0 years) who successfully achieved clinical pregnancy, seven patients aged 28-35 years had miliary TB during pregnancy, with two patients having a complication of TB meningitis. All these patients presented with fever. Notably, old TB lesions were detected on CXR in six patients before IVF-ET; nevertheless, no anti-TB therapy was administered. Furthermore, salpingography revealed oviduct obstruction in all patients (7/7). Patients received anti-TB therapy following a diagnosis of miliary TB and were clinically cured. However, pregnancy was terminated due to spontaneous (4/7) and induced (3/7) abortion.

conclusionsTB reactivation, mostly as miliary TB and TB meningitis, is severe in pregnant women after IVF-ET and deleterious to pregnancy outcomes. Signs of prior TB on CXR may be risk factors for TB reactivation during pregnancy.

Indexed as

Infertility, FemaleTuberculosis, MiliaryAdultEmbryo TransferFemaleFertilization in VitroHumansPregnancyPregnancy OutcomeRetrospective StudiesEmbryo transferInfertilityIn vitro fertilizationMiliary tuberculosis

Identifiers

PMID34488670
PMCPMC8419986
OpenAlexW3197084370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.