Evidence map›Paper›PMID 34488544›Full record

ReviewChannels (Austin, Tex.)2021

Molecular mechanisms of activation and regulation of ANO1-Encoded Ca

M B Hawn, E Akin, H C Hartzell, I A Greenwood, N Leblanc

Open access · goldAbstract readReview
In one paragraph

Review in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Review
  4. Allosteric coupling between PIPProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Interplay of CaThe Journal of physiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Niclosamide potentiates TMEM16A and induces vasoconstriction.The Journal of general physiology · 2024
    Article
  11. The role of anoctamin 1 in liver disease.Journal of cellular and molecular medicine · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

M B HawnDepartment of Pharmacology and Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
E AkinDepartment of Pharmacology and Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
H C HartzellDepartment of Cell Biology, Emory University School of Medicine, USA.
I A GreenwoodDepartment of Vascular Pharmacology, St. George's University of London, UK.
N LeblancDepartment of Pharmacology and Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, United States.
University of Nevada, Reno · USEmory University · USSt George's, University of London · GB

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
Retinal Degeneration and Chloride ChannelsR01EY014852 · NEI · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2003 to 2020
$5.7M
Role of ANO1 Channels and Its Regulation by PIP2 in EC-Coupling in Pulmonary Artery MyocytesR01HL146054 · NHLBI · UNIVERSITY OF NEVADA RENO · PI EARLEY, SCOTT, LEBLANC, NORMAND · 2019 to 2022
$2.0M
Molecular Physiology of TMEM16/Anoctamin ProteinsR01GM132598 · NIGMS · EMORY UNIVERSITY · PI HARTZELL, H. CRISS · 2019 to 2022
$1.5M
British Heart FoundationNEI NIH HHS R01 EY014852NHLBI NIH HHS R01 HL146054NIGMS NIH HHS P20 GM130459NIGMS NIH HHS R01 GM132598
6 · The paper itself

Abstract

Ca

Indexed as

CalciumChloride ChannelsAnoctamin-1AnoctaminsCalmodulinAnoctamin-1AnoctaminsCalciumCalmodulinChloride ChannelsANO1anoctamin-1Calcium-activated chloride channelcalcium bindingCaMKIIphosphorylationPIP2regulationstructureTMEM16A

Identifiers

PMID34488544
PMCPMC8480199
OpenAlexW3198508622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.