Evidence map›Paper›PMID 34488469›Full record

ArticleDiabetes & vascular disease research

Polymorphism in the

Dong-Hwa Lee, Gun Woo Won, Yong Hee Lee, Jong Sung Shin, Eu Jeong Ku, Tae Keun Oh, Hyun Jeong Jeon

Open access · diamondAbstract read
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dong-Hwa LeeDepartment of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Korea.ORCID 0000-0002-1552-3205
Gun Woo WonDepartment of Biochemistry, Chungbuk National University College of Medicine, Cheongju, Korea.
Yong Hee LeeDepartment of Biochemistry, Chungbuk National University College of Medicine, Cheongju, Korea.
Jong Sung ShinHanmi Internal Medicine Clinic, Cheongju, Korea.
Eu Jeong KuDepartment of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Korea.
Tae Keun OhDepartment of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Korea.
Hyun Jeong JeonDepartment of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Korea.
Chungbuk National University Hospital · KRChungbuk National University · KRHanmi Pharmaceutical (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSLC2A1 polymorphism may play a role in the smooth muscle cell proliferation and extracellular matrix synthesis in vessels. However, the role of SLC2A1 polymorphism on diabetic cardiovascular disease (CVD) have not yet been identified. In this study, we aimed to investigate the association between SLC2A1 HaeIII polymorphism and CVD in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.

methodsA total of 846 patients with T2DM who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of SLC2A1 gene was determined by real time polymerase chain reaction method. Genotyping results were presented GG, AG, or AA. Subgroup analysis was performed according to duration of T2DM (⩽10, 11-20, >20 years).

resultsThe AA genotype was significantly associated with higher prevalence of CVD in patients with DM duration less than 10 years (26.3% vs 9.2%,

conclusionsThe SLC2A1 HaeIII polymorphism was associated with CVD in Korean patients with T2DM with short disease duration.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenotypeGlucose Transporter Type 1HumansPolymorphism, Single NucleotideGlucose Transporter Type 1SLC2A1 protein, humancardiovascular diseasediabetic complicationsSLC2A1 polymorphismtype 2 diabetes mellitus

Identifiers

PMID34488469
PMCPMC8481723
OpenAlexW3196746328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.