Evidence map›Paper›PMID 34488449›Full record

ArticlemBio2021

Independent Promoter Recognition by TcpP Precedes Cooperative Promoter Activation by TcpP and ToxR.

A L Calkins, L M Demey, J D Karslake, E D Donarski, J S Biteen, V J DiRita

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Structures ofScience advances · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. ToxR activates theProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

A L Calkins *Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
L M Demey *Department of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.
J D KarslakeBiophysics Program, University of Michigan, Ann Arbor, Michigan, USA.
E D DonarskiBiophysics Program, University of Michigan, Ann Arbor, Michigan, USA.
J S BiteenDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-2038-6484
V J DiRitaDepartment of Microbiology and Molecular Genetics, Michigan State Universitygrid.17088.36, East Lansing, Michigan, USA.ORCID 0000-0003-3617-7011
University of Michigan · USMichigan State University · US

Funding

Integrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5M
Tools for Creating a Super-Resolution Interaction Map of Subcellular Dynamics in Living Bacteria CellsR21GM128022 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BITEEN, JULIE · 2018 to 2019
$408k
NIGMS NIH HHS R21 GM128022NIGMS NIH HHS T32 GM092715
6 · The paper itself

Abstract

Cholera is a diarrheal disease caused by the Gram-negative bacterium Vibrio cholerae. To reach the surface of intestinal epithelial cells, proliferate, and cause disease, V. cholerae tightly regulates the production of virulence factors such as cholera toxin (

Indexed as

Promoter Regions, GeneticBacterial ProteinsCholeraDNA-Binding ProteinsGene Expression Regulation, BacterialHumansProtein BindingTranscription FactorsVibrio choleraeBacterial ProteinsDNA-Binding ProteinsTCPP protein, Vibrio choleraetoxR protein, Vibrio choleraeTranscription Factorsgene expressionmembrane proteinssingle moleculesuperresolution

Identifiers

PMID34488449
PMCPMC8546550
OpenAlexW3198102389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.