Evidence map›Paper›PMID 34488447›Full record

ArticlemBio2021

RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote.

Hanbang Zhang, Juliana Veira, Sarah Twitty Bauer, Christopher Yip, Upinder Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Exploring virulence and stress response inMicrobiology spectrum · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hanbang ZhangDivision of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.
Juliana VeiraDivision of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.
Sarah Twitty BauerDivision of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.
Christopher YipDivision of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.
Upinder SinghDivision of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.ORCID 0000-0003-0630-0306
Stanford University · US

Funding

Small RNA regulation of gene expression in EntamoebaR01AI121084 · NIAID · STANFORD UNIVERSITY · PI SINGH, UPINDER · 2016 to 2020
$3.1M
NIAID NIH HHS R01 AI121084
6 · The paper itself

Abstract

Entamoeba histolytica is a protozoan parasite that causes amebiasis in humans and is a major health concern in developing countries. Our previous work revealed a functional RNA interference (RNAi) pathway in

Indexed as

Protein Interaction MapsRNA InterferenceEntamoeba histolyticaGene Expression RegulationMetabolic Networks and PathwaysProtozoan ProteinsRNA-Induced Silencing ComplexProtozoan ProteinsRNA-Induced Silencing ComplexArgonautemass spectrometryparasiteparasitologyRISCRNAiRNA interference

Identifiers

PMID34488447
PMCPMC8546589
OpenAlexW3197591519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.