Evidence map›Paper›PMID 34488445›Full record

ArticlemBio2021

LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense.

Ai-Yu Gong, Yang Wang, Min Li, Xin-Tian Zhang, Silu Deng, Jessie M Chen, Eugene Lu, Nicholas W Mathy, Gislaine A Martins, Juliane K Strauss-Soukup and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. LncRNA BACE1-AS delays the propagation ofMicrobiology spectrum · 2025
    Article
  5. Microbiology spectrum · 2025
    Article
  6. Review
  7. Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ai-Yu Gong *Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
Yang Wang *Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Min LiDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Xin-Tian ZhangDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Silu DengDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.
Jessie M ChenDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Eugene LuDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Nicholas W MathyDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.
Gislaine A MartinsDeptartments of Medicine and Biomedical Sciences, Research Division of Immunology Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Juliane K Strauss-SoukupDepartment of Chemistry, Creighton University College of Arts and Sciences, Omaha, Nebraska, USA.
Xian-Ming ChenDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0001-9848-2244
Creighton University · USCedars-Sinai Medical Center · US

Funding

Molecular Basis of Intestinal CryptosporidiosisR01AI116323 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2015 to 2025
$4.2M
LincRNAs in Mucosal Defense to AIDS Opportunistic Pathogen CryptosporidiumR01AI136877 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2018 to 2022
$1.9M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
LncRNA regulation of Type I IFN signaling in intestinal epitheliumR21AI156370 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2021 to 2022
$432k
Intestinal Stem Cell Responses to Cryptosporidium InfectionR21AI141325 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2020 to 2021
$415k
NCRR NIH HHS G20 RR024001NIAID NIH HHS R01 AI116323NIAID NIH HHS R01 AI136877NIAID NIH HHS R21 AI141325NIAID NIH HHS R21 AI156370
6 · The paper itself

Abstract

Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully understood. We report here that a long noncoding RNA (lncRNA), GenBank accession no. XR_001779380, was increased in abundance in murine intestinal epithelial cells following infection by

Indexed as

Age FactorsAnimalsCryptosporidiosisCryptosporidium parvumEpithelial CellsHumansImmunity, MucosalInterferon-gammaIntestinal MucosaMiceNF-kappa BRNA, Long NoncodingToll-Like Receptor 4Interferon-gammaNF-kappa BRNA, Long NoncodingToll-Like Receptor 4Cryptosporidiumgastrointestinal infectionhistone methylationinnate immunityinterferon gammalncRNAsPias1Prdm1Swi/Snf

Identifiers

PMID34488445
PMCPMC8546593
OpenAlexW3197533995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.