Evidence map›Paper›PMID 34488438›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease.

Pengfei Sun, Nitin Kumar, Adrienne Tin, Jing Zhao, Michael R Brown, Zesen Lin, Min-Lee Yang, Qiwen Zheng, Jia Jia, Lawrence F Bielak and 12 more

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Differential cardiovascular and autonomic responses to structurally distinct intermittent hypoxia paradigms in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 3 countries.

Pengfei Sun *Department of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).
Nitin Kumar *Division of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.
Adrienne TinJohns Hopkins Bloomberg School of Public Health, MD (A.T., J.C.).ORCID 0000-0002-4207-5866
Jing ZhaoDepartment of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., B.Y., E.B., A.C.M.).
Zesen LinDepartment of Pharmacology (Z.L.), University of Michigan Medical School, Ann Arbor.
Min-Lee YangDivision of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.
Qiwen ZhengKey Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China (Q.Z.).
Jia JiaDepartment of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor (L.F.B., S.L.R.K.).ORCID 0000-0002-3443-8030
Bing YuHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., B.Y., E.B., A.C.M.).
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., B.Y., E.B., A.C.M.).
Kristina L HunkerDivision of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0003-1032-4757
Josef CoreshJohns Hopkins Bloomberg School of Public Health, MD (A.T., J.C.).ORCID 0000-0002-4598-0669
Y Eugene ChenDivision of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0003-2357-7825
Yong HuoDepartment of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor (L.F.B., S.L.R.K.).
Rami KhoriatyDivision of Hematology, Department of Internal Medicine and Department of Cell and Developmental Biology (R.K.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0003-2539-5953
Xiang ZhouDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor (X.Z.).
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., B.Y., E.B., A.C.M.).ORCID 0000-0001-6381-4296
Yan ZhangDepartment of cardiology, Peking University First hospital, Beijing, China (P.S., J.Z., J.J., Y.H., Y.Z.).ORCID 0000-0002-7508-4160
Santhi K GaneshDivision of Cardiovascular Medicine, Department of Internal Medicine (N.K., M.-L.Y., K.L.H., Y.E.C., S.K.G.), University of Michigan Medical School, Ann Arbor.ORCID 0000-0002-3663-5249
University of Michigan · USPeking University · CNThe University of Texas Health Science Center at Houston · USJohns Hopkins University · USBeijing Institute of Genomics · CNMichigan Department of Health and Human Services · USStatistical Service · CY

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
The molecular pathophysiology of the congenital dyserythropoietic anemiasR01HL148333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rami Khoriaty · 2019 to 2026
$4.6M
Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and BloodR01HL087641 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2006 to 2008
$3.7M
Genetic Studies of The Impact of Hematologic Traits On Cardiovascular DiseaseR01HL122684 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2015 to 2019
$3.4M
Genetic and Genomic Analysis of Arterial DysplasiaR01HL139672 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2018 to 2021
$2.9M
GWA for Gene-Environment Interaction Effects Influencing CHDU01HG004402 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2007 to 2009
$1.6M
NCATS NIH HHS UL1 TR002240NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL122684NHLBI NIH HHS R01 HL139672NHLBI NIH HHS R01 HL148333
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBlood PressureCoronary Artery DiseaseCross-Sectional StudiesErythropoietinFemaleHumansHypertensionMaleMembrane ProteinsMiceMice, Inbred C57BLMiddle AgedProspective StudiesReceptor, Platelet-Derived Growth Factor alphaSerine EndopeptidasesErythropoietinMembrane ProteinsReceptor, Platelet-Derived Growth Factor alphaSerine EndopeptidasesTMPRSS6 protein, humancoronary artery diseaseerythropoietinhypertensionrisk factors

Identifiers

PMID34488438
PMCPMC8516734
OpenAlexW3196535967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.